Abstract
Purpose
We aimed to evaluate the role of caffeinated beverage intake as a potential trigger
of migraine headaches on that day or on the following day.
Methods
In this prospective cohort study, 101 adults with episodic migraine completed electronic
diaries every morning and evening. Ninety-eight participants completed at least 6
weeks of diaries in March 2016-October 2017. Every day, participants reported caffeinated
beverage intake, other lifestyle factors, and the timing and characteristics of each
migraine headache. We compared a participant's incidence of migraines on days with
caffeinated beverage intake to the incidence of migraines among the same individual
on days with no intake, accounting for day of week. We used conditional logistic regression
to estimate odds ratios (OR) and 95% confidence intervals.
Results
Among 98 participants (86 women, 12 men) with mean age 35.1 years, 83% white, and
10% Hispanic or Latino, the average age when headaches started was 16.3 years. In
total, the participants reported 825 migraines during 4467 days of observation. There
was a statistically significant nonlinear association between the number of caffeinated
beverages and the odds of migraine headache occurrence on that day (P-quadratic trend = .024), though estimates for each level of intake were not statistically
significant. The associations varied according to habitual intake and oral contraceptive
use.
Conclusions
There was a nonlinear association between caffeinated beverage intake and the odds
of migraine headache occurrence on that day. This suggests that high levels of caffeinated
beverage intake may be a trigger of migraine headaches on that day.
Keywords
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Article Info
Publication History
Published online: August 08, 2019
Footnotes
Funding: This work was conducted with support from the National Institute of Neurological Disorders and Stroke (R21-NS091627), the American Sleep Medicine Foundation, Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL 1TR002541), and financial contributions from Harvard University and its affiliated academic health care centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, or the National Institutes of Health.
Conflict of Interest: None.
Authorship: All authors had access to the data and participated in writing the manuscript
Identification
Copyright
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