In 1892, Osler
first observed the association between worsening asthma and a distended stomach.
However, it has only been in the past 2 decades that clinicians’ awareness of gastroesophageal
reflux disease (GERD) as the cause of pulmonary diseases has increased. The majority
of studies evaluating this association have focused on asthma, but other potential
adult pulmonary manifestations of GERD include chronic bronchitis, aspiration pneumonia,
bronchiectasis, and interstitial pulmonary fibrosis.
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References
- The Principles of Internal Medicine. Appleton, New York1892
- Prevalence and clinical spectrum of gastroesophageal reflux.Gastroenterology. 1997; 112: 1448-1456
- Asthma.N Engl J Med. 1992; 327: 1928-1937
- The role of gastroesophageal reflux in chronic cough and asthma.Chest. 1997; 111: 1389-1402
- Prevalence of gastroesophageal reflux symptoms in asthma.Chest. 1996; 109: 316-322
- Difficult-to-control asthma.Chest. 1993; 103: 1662-1669
- Oesophageal function in asthmatics.Eur J Respir Dis. 1981; 62: 87-94
- Prevalence of oesophagitis in asthmatics.Gut. 1992; 33: 872-876
- Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy.Gastroenterology. 1990; 99: 613-620
- Gastro-oesophageal reflux prevalence and relationship with bronchial reactivity in asthma.Eur Respir J. 1997; 10: 2255-2259
- Gastroesophageal reflux and asthma.Ann Allergy. 1978; 41: 224-226
- Acid-induced esophagobronchial cardiac reflexes in humans.Gastroenterology. 1990; 99: 71-73
- Gastroesophageal reflux-induced bronchoconstriction.Chest. 1994; 106: 731-737
- Autonomic regulation in asthmatics with gastroesophageal reflux.Chest. 1997; 111: 65-70
Harding SM, Guzzo MR, Maples RV, et al. Gastroesophageal reflux induced bronchoconstriction: vagolytic doses of atropine diminish airway responses to esophageal acid infusion. Am J Respir Crit Care Med. 1995;151:A589. Abstract.
- Effects of spontaneous and stimulated gastroesophageal reflux on sleeping asthmatics.Am Rev Respir Dis. 1990; 141: 1394-1399
- The effect of acid perfusion of the esophagus on ventilation and respiratory sensation.Am J Respir Crit Care Med. 1998; 157: 1058-1062
- Intraesophageal perfusion of acid increases the bronchomotor response to methacholine and to isocapnic hyperventilation in asthmatic subjects.Am Rev Respir Dis. 1986; 134: 986-999
- Comparison of airway responses following tracheal or esophageal acidification in the cat.Gastroenterology. 1984; 87: 872-881
- Simultaneous tracheal and oesophageal pH measurements in asthmatic patients with gastro-esophageal reflux.Thorax. 1995; 50: 201-204
- Effect of conservative treatment of oesophageal dysfunction on bronchial dysfunction on bronchial asthma.Eur J Respir Dis. 1981; 62: 190-197
- Relationship between asthma and gastroesophageal reflux.Thorax. 1981; 36: 116-121
- Anti-reflux treatment in asthma.Arch Intern Med. 1987; 147: 56-60
- Ambulatory pH monitoring of gastro-esophageal reflux in Amorning dipper asthmatics.BMJ. 1988; 297: 1371-1373
- Effects on ranitidine treatment on patients with asthma and a history of gastroesophageal reflux:a double blind crossover study.Thorax. 1989; 44: 19-23
- Gastroesophageal reflux and bronchial asthma. prevalence and effect of cisapride therapy.J Pediatr Gastroenterol Nutr. 1993; 17: 265-270
- Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux? A double-blind, placebo-controlled crossover study.Dig Dis Sci. 1994; 39: 2127-2133
- Adult asthma and gastroesophageal reflux.Aust N Z J Med. 1996; 26: 671-676
- Asthma and gastroesophageal reflux.Am J Med. 1996; 100: 395-405
- Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux.Am J Gastroenterol. 1998; 93: 1060-1063
- Omeprazole in the treatment of asthmatics with nocturnal symptoms and gastroesophageal reflux.Postgrad Med J. 1994; 70: 350-354
- No effects of high-dose omeprazole in patients with severe airway hyperresponsiveness and symptomatic gastroesophageal reflux.Eur Resp J. 1998; 11: 1070-1074
- Gastroesophageal reflux and hiatal hernia.J Thoracic Cardiovasc Surg. 1967; 53: 21-32
- A silent gastroesophageal reflux.Dis Chest. 1962; 42: 42-45
- Esophageal reflux as a trigger in asthma.N Y State J Med. 1966; 66: 3030-3032
- Hiatus hernia and the respiratory tract.Ann Thorac Surg. 1977; 24: 448
- Is gastroesophageal reflux a factor in some asthmatics?.Am J Gastroenterol. 1987; 82: 119-126
- Surgical treatment of gastroesophageal reflux in 10 patients with severe asthma.Respiration. 1989; 56: 110-115
- Long-term results of surgical treatment for gastroesophageal reflux in asthmatic patients.Chest. 1989; 96: 40-45
- Chronic respiratory symptoms and occult gastroesophageal reflux.Ann Surg. 1990; 211: 337-345
- Outcome of respiratory symptoms after antireflux surgery on patients with gastroesophageal reflux disease.Arch Surg. 1996; 131: 489-492
- Respiratory symptoms in patients with gastroesophageal reflux disease following medical therapy and antireflux surgery.Am J Surg. 1997; 174: 639-643
- Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux.Chest. 1991; 9: 1330-1335
Sontag S, O’Connel S, Khandelwal S, et al. Anti-reflux surgery in asthmatics with reflux (GERD) improves pulmonary symptoms and function. Gastroenterology. 1990;98:A128. Abstract.
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Published online: August 16, 2004
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© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
