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Enhancing progressive multifocal leukoencephalopathy: an indicator of improved immune status?

      Progressive multifocal leukoencephalopathy (PML) occurs in 1% to 4% of patients with acquired immunodeficiency syndrome (AIDS) (
      • Berger J.R.
      • Moskowitz L.
      • Fischl M.
      • Kelly R.E.
      The neurologic complication of AIDS frequently the initial manifestation.
      ,
      • Levy R.M.
      • Bredesen D.E.
      • Rosenblum M.L.
      Neurological manifestations of the acquired immunodeficiency syndrome (AIDS) experience at UCSF and review of the literature.
      ,
      • Levy R.M.
      • Bredesen D.E.
      • Rosenblum M.L.
      Opportunistic central nervous system pathology in patients with AIDS.
      ,
      • Moskowitz L.B.
      • Hensley G.T.
      • Chan J.C.
      • et al.
      The neuropathology of acquired immunodeficiency syndrome.
      ). Its overall prognosis is poor, primarily because of the lack of effective therapy (
      • Moskowitz L.B.
      • Hensley G.T.
      • Chan J.C.
      • et al.
      The neuropathology of acquired immunodeficiency syndrome.
      ).
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