Somatostatin is reported to inhibit the proliferation of various kinds of cells, including
lymphocytes, through its receptors (
1
). Octreotide, a somatostatin analogue, has been used for the treatment of lymphomas,
although its effectiveness is unclear (
2
). We have cared for a patient with a low-grade mucosa-associated lymphoid tissue (MALT)
lymphoma of the stomach accompanied by pancreatic somatostatinoma. Here we report
that during the clinical course there were reciprocal changes in the plasma somatostatin
concentration and the progression of the lymphoma, suggesting an inhibitory effect
of plasma somatostatin on the proliferation of gastric MALT lymphoma.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Gut somatostatin.in: Walsh J.H. Comprehensive Endocrinology. Gut Peptides. Raven Press, New York1994: 123-146
- Evaluation of a somatostatin analog in the treatment of lymphoproliferative disorders.J Clin Oncol. 1995; 13: 2012-2015
- Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue after eradication of Helicobacter pylori.Lancet. 1993; 342: 575-577
- Differential effects of vasoactive intestinal peptide, substance P and somatostatin on immunoglobulin synthesis and proliferation by lymphocytes from Peyer’s patches, mesenteric lymph nodes, and spleen.J Immunol. 1986; 136: 152-156
- Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissue.Gastroenterology. 1992; 103: 1207-1214
- Gene rearrangements, Helicobacter pylori, and gastric MALT lymphoma.Lancet. 1994; 343: 1636
- The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori.Lancet. 1993; 342: 571-574
- Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentration of human stomach.Dig Dis Sci. 1992; 37: 409-416
Article Info
Publication History
Accepted:
August 20,
1998
Received in revised form:
August 20,
1998
Received:
December 12,
1997
Identification
Copyright
© 1998 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
