The cardiovascular dysmetabolic syndrome

  • Timothy C Fagan
    Requests for reprints should be addressed to Timothy C. Fagan, MD, University Health Care at Ventana Vista, 5620 North Kolb Road, Suite 166, Tucson, Arizona 85750
    Departments of Medicine and Pharmacology, University of Arizona College of Medicine, Tucson, Arizona, USA
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  • Prakash C Deedwania
    Cardiology Division, Department of Medicine, University of California, San Francisco, San Francisco, California, USA

    Stanford University Medical Center, Palo Alto, California, USA
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      A clustering of metabolic abnormalities associated with cardiovascular disease has been recognized since at least 1988.
      • Reaven G.M
      Role of insulin resistance in human disease.
      This clustering has been given many names including Syndrome X, The Deadly Quartet, and The Insulin Resistance Syndrome. For various reasons each of these names is unsatisfactory. The Western Working Group believes that cardiovascular dysmetabolic syndrome (CDS) is the name that best describes this group of abnormalities, because it emphasizes the cardiovascular consequences of these abnormalities, recognizes that they are distinguishable abnormalities, and indicates that any given patient may have some or all of the components of the syndrome.
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