Advertisement

Influence of exhaustive treadmill exercise on cognitive functioning in chronic fatigue syndrome

  • John J LaManca
    Correspondence
    Requests for reprints should be addressed to John J. LaManca, PhD, New Jersey Medical School, 88 Ross Street, East Orange, New Jersey 07018
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • Sue Ann Sisto
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • John DeLuca
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • Susan K Johnson
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • Gudrun Lange
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • Jacqueline Pareja
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • Sean Cook
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author
  • Benjamin H Natelson
    Affiliations
    Chronic Fatigue Syndrome Cooperative Research Center, University of Medicine and Dentistry of New Jersey–New Jersey Medical School, Newark, New Jersey, USA

    The Research Department, Kessler Institute for Rehabilitation, West Orange, New Jersey USA
    Search for articles by this author

      Abstract

      The purpose of this study was to determine the effect of exhaustive exercise on cognitive performance of patients with chronic fatigue syndrome (CFS) and sedentary healthy controls (CON). Subjects were 19 women with CFS and 20 CON. A test battery consisting of 4 cognitive tests (CTB) was given pre-, immediately post-, and 24 hours post-treadmill exercise to exhaustion. No differences were seen on the CTB pre-exercise. CFS patients improved at a slower rate than CON on the Symbol Digit Modalities Test (SDMT), Stroop Word Test (SWT), and Stroop Color Test (SCT). When compared with CON, a lower number of correct responses was seen for the CFS immediately postexercise on the SDMT (61 ± 3 vs 66 ± 2), SWT (137 ± 6 vs 146 ± 6), and SCT (99 ± 4 vs 107 ± 3), and 24 hours postexercise on the SDMT (64 ± 3 vs 69 ± 2), SWT (134 ± 7 vs 148 ± 5), and SCT (101 ± 4 vs 106 ± 3). We conclude that after physically demanding exercise, CFS subjects demonstrated impaired cognitive processing compared with healthy individuals.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Komaroff A.L
        • Buchwald D
        Symptoms and signs of chronic fatigue syndrome.
        Rev Infect Dis. 1991; 13: S8-S11
        • Peterson P.K
        • Sirr S
        • Grammith F.C
        • et al.
        Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients.
        Clin Diagn Lab Immunol. 1994; 1: 222-226
        • Lloyd A
        • Gandevia S
        • Brockman A
        • et al.
        Cytokine production and fatigue in patients with chronic fatigue syndrome and healthy control subjects in response to exercise.
        Clin Infect Dis. 1994; 18: S142-S146
        • Sisto S.A
        • LaManca J
        • Cordero D.L
        • et al.
        Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.
        Am J Med. 1996; 100: 634-640
        • DeLuca J
        • Johnson S
        Neuropsychological impairments in chronic fatigue syndrome, multiple sclerosis, and depression.
        J Neurol Neurosurg Psychiatry. 1995; 58: 38-43
        • DeLuca J
        • Johnson S.K
        • Natelson B.H
        Information processing efficiency in chronic fatigue syndrome and multiple sclerosis.
        Arch Neurol. 1993; 50: 301-304
        • Johnson S.K
        • Deluca J
        • Diamond B.J
        • Natelson B.H
        Selective impairment of auditory processing in chronic fatigue syndrome.
        Percept Mot Skills. 1996; 83: 51-62
        • Marshall P.S
        • Watson D
        • Steinberg P
        • et al.
        Assessment of cognitive function and mood in chronic fatigue syndrome.
        Biol Psychiatry. 1996; 39: 199-206
        • Marshall P.S
        • Forstot M
        • Callies A
        • et al.
        Cognitive slowing and working memory difficulties in chronic fatigue syndrome.
        Psychosom Med. 1997; 59: 58-66
        • Grafman J
        • Schwartz V
        • Dale J.K
        • et al.
        Analysis of neuropsychological functioning in patients with chronic fatigue syndrome.
        J Neurol Neurosurg Psychiatry. 1993; 56: 684-689
        • Schluederberg A
        • Straus S.E
        • Peterson P
        • et al.
        Chronic fatigue syndrome.
        Ann Intern Med. 1992; 117: 325-331
        • Holmes G.P
        • Kaplan J.E
        • Gantz N.M
        • et al.
        Chronic fatigue syndrome.
        Ann Intern Med. 1988; 108: 387-389
        • Fukuda K
        • Straus S.E
        • Hickie I
        • et al.
        Chronic fatigue syndrome.
        Ann Intern Med. 1994; 121: 953-959
        • Natelson B.H
        • Johnson S.K
        • Deluca J
        • et al.
        Reducing heterogeneity in chronic fatigue syndrome.
        Clin Infect Dis. 1995; 21: 1204-1210
        • Marcus S
        • Robbins L.W
        • Bucholz K
        Quick Diagnostic Interview Schedule III-R version 1. St. Louis University School of Medicine, St. Louis, MO1990
        • Golden C.J
        Stroop Color and Word Test A Manual for Clinical and Experimental Uses. Stoelting Company, Wood Dale, IL1978: 32
        • Smith A
        Symbol Digit Modalities Test Manual. Western Psychological Services, Los Angeles1982: 22
        • Ricker J.H
        • Axelrod B.N
        • Houlter B.D
        Clinical validation of the oral trail making test.
        Neuropsychiatry Neuropsychol Behav Neurol. 1996; 9: 50-53
        • Borg G.A.V
        Psychophysical bases of perceived exertion.
        Med Sci Sports Exerc. 1982; 14: 377-381
        • Thayer R.E
        The Biopsychology of Mood and Arousal. Oxford University Press, New York1989: A178-A180
        • Beck A.T
        • Ward C.H
        • Mendelson M
        An inventory for measuring depression.
        Arch Gen Psychiatry. 1961; 4: 561-571
        • Blair J.R
        • Spreen O
        Predicting premorbid IQ.
        Clin Neuropsychol. 1989; 3: 129-136
        • Chalder T
        • Berelowitz G
        • Pawlikowska T
        • et al.
        Development of a fatigue scale.
        J Psychosom Res. 1993; 37: 147-153
        • Scheffers M.K
        • Johnson R
        • Grafman J
        • et al.
        Attention and short-term memory in chronic fatigue syndrome patients.
        Neurology. 1992; 42: 1667-1675
        • McGlynn G.H
        • Laughlin N.T
        • Rowe V
        The effect of increasing levels of exercise on mental performance.
        Ergonomics. 1979; 22: 407-414
        • Gutin B
        • DiGennaro J
        Effect of a treadmill run to exhaustion on performance of simple addition.
        Res Exerc Sport. 1968; 39: 958-964
        • Flynn R.B
        Numerical performance as a function of prior exercise and aerobic capacity for elementary school boys.
        Res Q Exerc Sport. 1972; 43: 16-22
        • Heckler B
        • Croce R
        Effects of time of post-test after two durations of exercise on speed and accuracy of addition and subtraction by fit and less-fit women.
        Percept Mot Skills. 1992; 75: 1059-1065
        • Pleban R.J
        • Thomas D.A
        • Thompson H.L
        Physical fitness as a moderator of cognitive work capacity and fatigue onset under sustained combat-like operations.
        Behav Res Methods Instr Comput. 1985; 17: 86-89
        • Gutin B
        Effect of increase in physical fitness on mental ability following physical and mental stress.
        Res Q Exerc Sport. 1966; 37: 211-220
        • Tomporowski P.D
        • Ellis N.R
        Effects of exercise on cognitive processes.
        Psychol Bull. 1986; 99: 338-346
        • Easterbrook J.A
        The effect of emotion on cue utilization and the organization of behavior.
        Psychol Rev. 1959; 66: 183-201