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Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome

  • Ronald Glaser
    Correspondence
    Requests for reprints should be addressed to Ronald Glaser, PhD, Department of Medical Microbiology and Immunology, The Ohio State University College of Medicine, 2175 Graves Hall, 333 West 10th Avenue, Columbus, Ohio 43210
    Affiliations
    Department of Medical Microbiology and Immunology, Institute for Behavioral Medicine Research, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio USA
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  • Janice K. Kiecolt-Glaser
    Affiliations
    Department of Psychiatry, Institute for Behavioral Medicine Research, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio USA
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      Abstract

      The frequent The frequent association of an active viral infection with the symptoms of CFS led researchers to hypothesize that chronic fatigue syndrome (CFS) is induced by a virus. Results of these studies indicated that despite clinical support for this hypothesis, there were no clear data linking viruses to CFS. In this overview, we will explore the interrelation of the immune, endocrine, and central nervous systems, and the possibility that stress and/or the reactivation/replication of a latent virus (such as Epstein Barr virus) could modulate the immune system to induce CFS. Relevant research conducted in the developing field of psychoneuroimmunology will be reviewed, with a particular focus on cytokine synthesis, natural killer (NK) cell activity, and T-lymphocyte function, as they relate to CFS.
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