Abstract
Purpose: Several studies have provided support for a pro-atherogenic role for remnant
lipoproteins. Thus, the aim of this study was to compare remnant-like particle (RLP)
cholesterol levels in patients with coronary artery disease who were normolipidemic
with those in controls of similar age and gender. We also assessed the usefulness
of measuring RLP-cholesterol levels in patients with type III dyslipidemia.
Subjects and methods: Remnant-like particle cholesterol levels were measured in 63
normolipidemic men with coronary artery disease and 23 male controls of similar age
as well as in 15 patients with type III dyslipidemia and 103 controls, using an immunoaffinity
method.
Results: Remnant-like particle cholesterol levels were significantly increased in
men with coronary artery disease compared with controls (7.6 ± 3.8 mg/dL versus 5.7
± 1.9 mg/dL, P <0.01). In patients with coronary artery disease, RLP-cholesterol levels were correlated
with total triglyceride and non–high-density-lipoprotein (HDL) cholesterol levels,
but not with HDL-cholesterol levels. RLP-cholesterol levels were significantly elevated
in patients with type III dyslipidemia (median 119, range 31 to 240 mg/dL) compared
with controls (median 5.6, range 2.2 to 10.5 mg/dL, P <0.001).
Conclusion: Normolipidemic men with coronary artery disease have increased levels
of RLP-cholesterol that is not detected with conventional lipid screening. The RLP-cholesterol
assay is a simple method for detecting high concentrations of remnant lipoproteins
in patients with type III dyslipidemia.
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Article info
Publication history
Published online: August 16, 2004
Accepted:
February 25,
1998
Received in revised form:
February 25,
1998
Received:
August 20,
1997
Identification
Copyright
© 1998 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
