Advertisement

Metformin-induced Acute Hepatitis

      Metformin and phenformin are biguanide oral hypoglycemic agents introduced for treatment of non–insulin-dependent diabetes mellitus (NIDDM) during the 1950’s. These agents were voluntarily withdrawn from the American market in the 1970s following reports that phenformin-induced a lactic acidosis and was associated with increased cardiovascular mortality (
      • Williams R.H.
      • Palmer J.P.
      Farewell to phenformin for treating diabetes mellitus.
      ). More recently, metformin has been reintroduced for use in patients with NIDDM. To this date, only a single case of metformin-induced hepatitis has been reported (
      • Cubuken A.
      • Yilmaz M.T.
      • Satman I.
      • et al.
      Metformin kullanimina bagli bir akut hepatit vakasi (metformin-induced hepatitis).
      ). This report describes the first American case of severe acute hepatitis attributed to this oral hypoglycemic agent.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Williams R.H.
        • Palmer J.P.
        Farewell to phenformin for treating diabetes mellitus.
        Ann Intern Med. 1975; 83: 567-568
        • Cubuken A.
        • Yilmaz M.T.
        • Satman I.
        • et al.
        Metformin kullanimina bagli bir akut hepatit vakasi (metformin-induced hepatitis).
        Tip Fak Mecm. 1991; 54: 447-452
        • Wilcock C.
        • Wyre N.D.
        • Bailey C.J.
        Subcellular distribution of metformin in rat liver.
        J Pharm Pharmacol. 1991; 43: 442-444
        • Bailey C.J.
        Biguanides and NIDDM.
        Diabet Care. 1992; 15: 755-772