Quinine sulphate and its d-stereoisomer quinidine are drugs that are extensively used
for diverse and common indications such as malaria or nocturnal leg cramps (quinine),
and in the treatment of arrhythmias (quinidine). Quinine sulphate is also a common
ingredient of many beverages. Thus, even adverse effects that are rare may be encountered
and should be well recognized, especially when they are potentially serious. Quinine
ingestion and quinine-dependent antibodies have been recently reported to be associated
with the hemolytic uremic syndrome in several patients (
1.
,
2.
,
3.
). We report a patient whose clinical presentation twice mimicked septic shock while
in fact it was due to a variant form of quinine toxicity, with partial hemolytic uremic
syndrome.To read this article in full you will need to make a payment
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References
- Quinine-induced disseminated intravascular coagulation.Lancet. 1990; 336: 1535-1537
- Recurrent pancytopenia, coagulopathy, and renal failure associated with multiple quinine-dependent antibodies.Ann Intern Med. 1993; 119: 215-217
- Quinine-induced immune thrombocytopenia with hemolytic uremic syndrome.Am J Hematol. 1994; 47: 283-289
- Characterization of multiple quinine-dependent antibodies in a patient with episodic hemolytic uremic syndrome and immune agranuocytosis.Blood. 1992; 80: 241-248
- Quinine sensitivity.Ann Intern Med. 1993; 119: 243-244
- Drug products for the treatment and/or prevention of nocturnal leg cramps for over-the-counter human use.Federal Register. 1994; 59: 43234-43252
Article Info
Publication History
Published online: August 16, 2004
Accepted:
January 15,
1998
Received in revised form:
January 15,
1998
Received:
November 24,
1997
Identification
Copyright
© 1998 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
