The diagnosis of Graves’ disease is typically made after a patient presents with symptoms
of the disease. Usual complaints are nervousness, loose stools, weakness, fatigue,
unexplained weight loss, irritability or heat intolerance, often of insidious and
uncertain onset (
1.
). However, little is known about its presymptomatic phase and whether its onset is
insidious or abrupt. In this case report, we document the onset of Graves’ disease
and its presymptomatic phase in the setting of a controlled feeding study. Salient
features of this case include the abrupt onset of the illness and a prolonged, virtually
asymptomatic phase.To read this article in full you will need to make a payment
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References
- Autoimmune thyroid disease.Endocrine Rev. 1984; 5: 309-355
Sacks FM, Obarzanek E, Windhauser MM, et al, for the DASH Investigators. Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH). A multi-center controlled-feeding study of dietary patterns to lower blood pressure. Ann Epidemiol.1995;5:108–118.
Appel LJ, Moore TJ, Obarzanek E, et al, for the DASH Collaborative Research Group. A clinical trial of the effects of dietary patterns on blood pressure. NEJM.1997;336:1117–1123.
Article info
Publication history
Published online: August 16, 2004
Accepted:
December 2,
1997
Received in revised form:
December 2,
1997
Received:
May 2,
1997
Footnotes
☆Supported by Grants HL50981, HL54906, and HL02642 from the National Heart, Blood and Lung Institute, RR00722 from the National Center for Research Resources of the National Institutes of Health, and American Heart Association—Maryland Affiliate Research Fellowship Award.
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© 1998 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
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