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Concentrations of Cefmenoxime in Human Tissues

  • Author Footnotes
    b From the Konig-Ludwig Haus der Universitat Wurzburg, Wurzburg, Germany.
    Wolfgang Robens
    Correspondence
    Requests for reprints should be addressed to Dr. Wolfgang Robens, Konig-Ludwig Haus der Universitat Wurzburg, Brettreichstrasse 11, D-8700 Wurzburg, Germany.
    Footnotes
    b From the Konig-Ludwig Haus der Universitat Wurzburg, Wurzburg, Germany.
    Affiliations
    Wurzburg, Germany
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  • Author Footnotes
    b From the Konig-Ludwig Haus der Universitat Wurzburg, Wurzburg, Germany.
      This paper is only available as a PDF. To read, Please Download here.
      Concentration levels of cefmenoxime were studied in human bone, muscle, fascia, cerebrospinal fluid, and synovial fluid. Tissue samples were taken 30 to 50 minutes after intravenous injection of 2,000 mg of cefmenoxime just before operation in patients undergoing orthopedic surgery. Levels were compared with those in the blood serum of the same patients. Cefmenoxime levels were also compared with levels of other cephalosporins examined by the same techniques and, with one exception, were found to be higher than those produced by the other agents. Cefmenoxime does not produce undesirable side effects, as do the other cephalosporins. Assay techniques for various tissues are described.
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