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Pharmacokinetic Study of Cefmenoxime (SCE 1365-CMX) in Healthy Adults

  • Author Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Jean-Bernard Fourtillan
    Correspondence
    Requests for reprints should be addressed to Prof. J-B Fourtillan, 4 Rue des Gaillards, 86000 Poitiers, France.
    Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Affiliations
    Poitiers, France
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  • Author Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    André Bryskier
    Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Affiliations
    Argenteuil, France
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  • Author Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Alain Mignot
    Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Affiliations
    Poitiers, France
    Search for articles by this author
  • Author Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    F. Borsa
    Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Affiliations
    Rouen, France
    Search for articles by this author
  • Author Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Guy Humbert
    Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
    Affiliations
    Rouen, France
    Search for articles by this author
  • Author Footnotes
    a From the Cerom Center, Poitiers, France, the Laboratoire de Bactériologie, Centre Hôspitalier d'Argenteuil, France, and the Hôspital de Rouen, Médecine Interne, Rouen, France.
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      Abstract

      Cefmenoxime pharmacokinetics were investigated in six healthy volunteers after intravenous and intramuscular administration of 0.5, 1, and 2 g. Blood and urine samples were analyzed by reversedphase high-pressure liquid chromatography using ultraviolet detection at 275 nm. The assay is precise and linear up to 200 µg/ml−1, with µg/ml−1 as the limit of detection. Linearity of cefmenoxime kinetics was demonstrated because the area under the plasma concentrations is proportional to studied doses. Eight hours after 1 g of cefmenoxime intramuscularly, mean plasma concentrations are, respectively, 0.6 ± 0.1 and 0.3 ± 0.1 µg/ml−1. Intramuscular Cefmenoxime is rapidly absorbed (Ka = 7.28 hours−1) with complete bioavailability (F = 0.99); apparent volume of distribution is 0.35 liters/kg−1 and elimination half-life 1.5 hours. The fraction of Cefmenoxime excreted unchanged in the urine after intramuscular administration is 0.72, indicating a major contribution of renal clearance in total clearance. Experimental data after intramuscular administration were well fitted with a two-compartment model.
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