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Influence of Cefmenoxime, Ceftriaxone, Latamoxef, and Ceftazidime on the Lysis of Klebsiella pneumoniae: A Light and Electron Microscopic Study

  • Author Footnotes
    1 Department of Medical Microbiology of the University of Kiel, Kiel, Federal Republic of Germany.
    Uwe Ullmann
    Correspondence
    Requests for reprints should be addressed to Dr. Uwe Ullmann, Department of Medical Microbiology of the University of Kiel, Brunswiker Str. 2-6, 2300 Kiel, Federal Republic of Germany.
    Footnotes
    1 Department of Medical Microbiology of the University of Kiel, Kiel, Federal Republic of Germany.
    Affiliations
    Kiel, Federal Republic of Germany
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  • Author Footnotes
    1 Department of Medical Microbiology of the University of Kiel, Kiel, Federal Republic of Germany.
    Ursula Hammer-Uschtrin
    Footnotes
    1 Department of Medical Microbiology of the University of Kiel, Kiel, Federal Republic of Germany.
    Affiliations
    Kiel, Federal Republic of Germany
    Search for articles by this author
  • Author Footnotes
    1 Department of Medical Microbiology of the University of Kiel, Kiel, Federal Republic of Germany.
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      The influence of antibiotics on the morphologic alterations of the cell wall of Klebsiella pneumoniae serotype K 17 has been studied by electron microscopy as well as by phase-contrast microscopy. Ceftazidime, cefmenoxime, ceftriaxone, and latamoxef were the antibiotics used. The effect of each concentration between 0.03 and 1,024 mg/liter was investigated on 5 × 107 bacteria per milliliter. Two different reactions could be detected: ceftazidime and latamoxef produced at first long forms and suddenly lysis; cefmenox me and ceftriaxone produced at first long forms, later spherical forms, and then gradually lysis.
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