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Clinical Results and Concentrations of Cefmenoxime in Serum, Amniotic Fluid, Mother's Milk, and Umbilical Cord

  • Author Footnotes
    1 Frauenklinik der University, Munich, West Germany
    E.R. Weissenbacher
    Correspondence
    Requests for reprints should be addressed to Dr. E. R. Weissenbacher, Frauenklinik der University, Marchioninistr 15, D-8000, Munich 70, West Germany.
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    1 Frauenklinik der University, Munich, West Germany
    Affiliations
    Munich, West Germany
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    1 Frauenklinik der University, Munich, West Germany
    D. Adams
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    1 Frauenklinik der University, Munich, West Germany
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    Munich, West Germany
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  • Author Footnotes
    1 Frauenklinik der University, Munich, West Germany
    K. Gutschow
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    1 Frauenklinik der University, Munich, West Germany
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    Munich, West Germany
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    1 Frauenklinik der University, Munich, West Germany
    C. Peters-Welts
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    1 Frauenklinik der University, Munich, West Germany
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    Munich, West Germany
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    1 Frauenklinik der University, Munich, West Germany
    H.G. Luehr
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    1 Frauenklinik der University, Munich, West Germany
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    Munich, West Germany
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    1 Frauenklinik der University, Munich, West Germany
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      Cefmenoxime administered intravenously was used to treat a variety of gynecologic and obstetric infections in 40 patients. Many were mixed infections. The mean age of the patients was 39.7 ± 2.39 years. The dosage of cefmenoxime was 2 g per day (n = 30) or 1 g per day (n =10). Cefmenoxime levels were assayed microbiologically in serum, milk, amniotic fluid, and placental tissues. The overall bacteriologic cure rate was 86 percent. Clinically, 100 percent of the patients were treated successfully. Side effects were generally mild, and in no case was treatment discontinued. Twelve hours after the last bolus injection, levels of cefmenoxime were 1.1 μg/ml in serum and 1.75 μg/ml in milk. Thirty minutes after a 1 g bolus injection in patients undergoing cesarean section, mean maternal serum concentrations were 33 μg/ml. Concentrations were 7.4 μg/ml in umbilical cord blood and 2.3 μg/ml in amniotic fluid.
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