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Cefmenoxime: In Vitro Activity

  • Author Footnotes
    a From the Pharmaceutical Discovery Division, Abbott Laboratories, North Chicago, Illinois.
    John M. Stamm
    Correspondence
    Requests for reprints should be addressed to John Stamm, Pharmaceutical Discovery, Abbott Laboratories, North Chicago, Illinois 60064.
    Footnotes
    a From the Pharmaceutical Discovery Division, Abbott Laboratories, North Chicago, Illinois.
    Affiliations
    North Chicago, Illinois
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  • Author Footnotes
    a From the Pharmaceutical Discovery Division, Abbott Laboratories, North Chicago, Illinois.
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      The in vitro activity of cefmenoxime (SCE-1365 or A-50912), a new semisynthetic cephalosporin antibiotic, was determined for a broad spectrum of 1,234 organisms isolated as part of a multiclinic study. The minimum inhibitory concentration (MIC) of cefmenoxime required to inhibit at least 90 percent of strains tested (MIC90) ranged from 0.12 to 8 µg/ml for Enterobacteriaceae. MIC90s were 0.015 and 0.06 µg/ml for Streptococcus pneumoniae and S. pyogenes, respectively, and 4 µg/ml for Staphylococcus aureus. Group D streptococci were less susceptible. The MIC90 of cefmenoxime for Neisseria gonorrhoeae and Hemophilus influenzae was 0.06 µg/mi. Cefmenoxime was less active against Pseudomonas aeruginosa, Acinetobacter species, and Bacteroides fragilis (MIC50 =16 µg/ml).
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