Clinical Communication to the Editor|Articles in Press

Popeye Deformity: A Red Flag for Wild-Type Transthyretin Amyloidosis

Published:February 02, 2023DOI:
      A 72-year-old man with past medical history of hypertension was referred to a cardiology consultation due to recent heart failure hospitalization and newly diagnosed atrial fibrillation. Physical examination revealed a large bulge on his anterior mid-upper left arm, more pronounced during elbow flexion (Figure). This deformity had developed several months before, after lifting a heavy object. He remembers hearing a “pop” sound, followed by a sudden sharp pain and weakness in his left arm. He did not seek medical care and started self-treatment with cryotherapy and nonsteroidal anti-inflammatory drugs. The pain totally relieved within a few days and no longer affected his daily life.
      FigurePatient's left arm in flexion position. A deformity (Popeye sign) is perceived in the anterior mid-upper arm.
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