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Myeloperoxidase: A Circulating Marker of Inflammation and Tooth Infection

Published:December 22, 2022DOI:https://doi.org/10.1016/j.amjmed.2022.12.008

      ABSTRACT

      BACKGROUND

      Atherosclerotic cardiovascular disease and tooth infection are common in primary care, and both significantly reduce quality of life. Our study aimed to examine signs of vascular inflammation associated with loss of tooth vitality before and after a single tooth extraction.

      METHODS

      An observational cohort study was performed with adults who had a non-vital tooth and an indicated desire for tooth extraction. Concentrations of total cholesterol (TC), HDL-cholesterol (HDL-C), high sensitivity C-reactive protein (hs-CRP), myeloperoxidase (MPO), and troponin T were measured in venous blood serum or plasma at baseline and 6-weeks after tooth extraction.

      RESULTS

      Circulating hs-CRP levels were > 3 mg/dL in 15 participants (68.2%) and MPO levels were > 350 pmol/L in 9 (40.9%) of 22 participants at baseline. After tooth extraction (n=18), MPO levels decreased significantly compared to baseline (p <0.00006) and hs-CRP levels moved directionally downward. The response rate for MPO was 88.9% (CI: 65.1% to 98.6%) from visit 1 to visit 2. Those with high MPO levels at baseline demonstrated larger reductions in MPO levels by visit 2 than those with lower baseline MPO levels (r=.81; P < 0.0001). Thirteen individuals (72.2%) achieved MPO levels < 350 pmol/L and 11 (61.1%) achieved hs-CRP levels < 3 mg/dL at visit 2. TC, HDL-C, and troponin T levels did not significantly change from visit 1 to visit 2.

      CONCLUSION

      A link between dental infection and circulating levels of inflammation was observed suggesting that oral infection could be a risk factor for atherosclerotic cardiovascular disease.

      Key Words

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