Abstract
Background
Obesity is associated with a high risk of heart failure. However, the contribution
of regional fat distribution evaluated using bioimpedance analysis toward heart failure
risk in the general population without cardiovascular disease has rarely been studied.
Methods
This study included 483,316 participants without heart failure and cardiovascular
disease from the UK Biobank study. The regional fat mass was determined by bioimpedance
analysis and calculated by dividing the square of height in meters (kg/m2). This study evaluated the association of regional fat mass (arm fat index [AFI],
trunk fat index [TFI], and leg fat index [LFI]) with the risk of incident heart failure
and whether regional fat mass adds a further prognostic value for heart failure besides
body mass index (BMI) in a large prospective cohort study.
Results
During the median 12.1 years, 3134 incident heart failure cases occurred. After adjustment
for BMI and other confounding factors, each 1-standard deviation increase in LFI was
associated with a 21% lower heart failure risk even after adjusting for BMI and other
confounding factors (hazard ratio [HR] 0.79; 95% confidence interval [CI], 0.73-0.85).
However, we did not observe heart failure-associated risks with AFI and TFI (HR 1.04;
95% CI, 0.99-1.09; HR 0.97, 95% CI, 0.91–1.04, respectively). Subgroup analysis demonstrated
that the protective role of LFI was more prominent in the elderly and female participants
(P < .01).
Conclusion
Regional fat measurement other than BMI can improve heart failure risk stratification;
leg fat plays a protective role, yet arm and trunk fat do not, in the general population
without cardiovascular disease.
Keywords
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Article info
Publication history
Published online: December 07, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Funding: This work was supported in part by National Natural Science Foundation of China project 82000298 and Natural Science Foundation of Hunan Province 2021JJ40883 to ZX.
Conflicts of Interest: The authors declare that they do not have any competing interests.
The study's funder played no role in study design, data arrangement, data statistics, or writing. The corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication
Authorship: All authors had access to the data and a role in writing the manuscript. They all have approved the manuscript and have agreed to its publication.
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