Abstract
Introduction
Sugar-sweetened and artificially sweetened beverages are routinely consumed worldwide.
Given their popularity, there has been much debate about the effect that these beverages
have on cardiovascular health. We sought to determine the exact relationship between
sugar-sweetened and artificially sweetened beverages consumption on cardiovascular
health.
Methods
All studies that reported an association between sugar-sweetened/artificially sweetened
beverages consumption and cardiovascular health were extracted from database inception
to September 2022 using keywords from several databases. We used the DerSimonian &
Laird random-effects method for the analysis.
Results
Of the total 16 prospective studies, 1,405,375 individuals were followed for a median
follow-up of 14.8 years. Compared with low sugar-sweetened and artificially sweetened
beverage consumption, a higher consumption of sugar-sweetened and artificially sweetened
beverages was associated with greater cardiovascular outcomes (hazard ratio [HR] of
1.27, 95% confidence interval [CI] of 1.16-1.40 and risk ratios of 1.16, 95% CI of
1.02-1.33). Similarly, compared with low artificially sweetened beverages consumption,
a higher consumption of artificially sweetened beverages was associated with greater
cardiovascular outcomes (HR of 1.32, 95% CI of 1.12-1.57). Likewise, compared with
low sugar-sweetened beverages consumption, a higher consumption of sugar-sweetened
beverages was associated with greater cardiovascular outcomes (HR of 1.21, 95% CI
of 1.07-1.37 and risk ratios of 1.22, 95% CI of 1.09-1.35).
Conclusions
Increasing consumption of sugar-sweetened and artificially sweetened beverages may
be correlated with an increased risk of developing cardiovascular/vascular complications
and mortality, albeit without causality of cardiovascular/vascular morbidity.
Keywords
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Article Info
Publication History
Published online: October 13, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Funding: None.
Conflicts of Interest: KN discloses Chair American Association of Clinical Endocrinology Obesity Consensus (AACE) Statement on Stigma/Diagnosis and Chair AACE CPG/algorithm task force. CK discloses Member of the American College of Cardiology Solution Set Oversight Committee, The American College of Cardiology/American Heart Association (ACC/AHA) Joint Committee on Clinical Data Standards, the American Heart Association Committee of the Council on Genomic and Precision Medicine, and the American College of Cardiology/American Heart Association (ACC/AHA) Task Force on Performance Measures, The Lancet Digital Health (Advisory Board), European Heart Journal Digital Health (Editorial board), Journal of the American Heart Association (Editorial board), JACC: Asia (Section Editor), The Journal of Scientific Innovation in Medicine (Associate Editor), and Frontiers in Cardiovascular Medicine (Associate Editor).
Authorship: All authors had access to the data and a role in writing the manuscript.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
