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Relationship between marijuana use and Overactive Bladder (OAB): a cross-sectional research of National Health and Nutrition Examination Survey (NHANES) 2005 to 2018

  • Author Footnotes
    # These authors contributed equally to this work.
    Shenhao Zhu
    Footnotes
    # These authors contributed equally to this work.
    Affiliations
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing, 210000, China
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  • Author Footnotes
    # These authors contributed equally to this work.
    Zhongyuan Wang
    Footnotes
    # These authors contributed equally to this work.
    Affiliations
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing, 210000, China
    Search for articles by this author
  • Author Footnotes
    # These authors contributed equally to this work.
    Zhijun Tao
    Footnotes
    # These authors contributed equally to this work.
    Affiliations
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing, 210000, China
    Search for articles by this author
  • Shangqian Wang
    Correspondence
    Corresponding authors: Dr. Zengjun Wang, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing 210000, China
    Affiliations
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing, 210000, China

    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China
    Search for articles by this author
  • Zengjun Wang
    Correspondence
    Corresponding authors: Dr. Zengjun Wang, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing 210000, China
    Affiliations
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, No 300 Guangzhou Road, Nanjing, 210000, China
    Search for articles by this author
  • Author Footnotes
    # These authors contributed equally to this work.
Published:September 20, 2022DOI:https://doi.org/10.1016/j.amjmed.2022.08.031

      Clinical Significance

      • In this large, nationally representative sample, participants with regular marijuana use at almost all frequencies had increased incidence and severity of overactive bladder.
      • Regular marijuana users had an increased nocturia frequency, while no significant difference in incontinence compared to non-regular users.
      • Currently, marijuana appears to be incompetent for the pharmacological treatment of refractory overactive bladder until more robust evidence becomes available.

      Abstract

      Background

      Current research is starting to focus on the medical value of marijuana and the possible health problems it can cause. Previous studies have shown that marijuana can relieve lower urinary tract symptoms, which can pose a significant public health burden. In this study, we assessed the association between regular marijuana use and overactive bladder as part of low urinary tract symptoms.

      Methods

      Data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 were obtained for analysis. The Overactive Bladder Symptom Score (OABSS) scale was used to define the presence of overactive bladder for each participant. Multivariate Logistic regression and ordinal logistic regression were used to analyze the association of marijuana use with the onset and severity of overactive bladder, respectively.

      Results

      We found that approximately 24% of the U.S. population reported regular marijuana use. Compared with nonregular users, regular marijuana users were younger, thinner, more likely to be male, smokers, low-income, less educated, unmarried, and non-Hispanic white/black. Multivariate logistic regression revealed that marijuana exposure may be an independent risk factor for overactive bladder (OR 1.39, 95% CI 1.16-1.66). Ordinal logistic regression results showed that marijuana exposure was associated with the severity of overactive bladder (OR 1.45, 95% CI 1.30-1.60). Moreover, all frequencies of regular use showed almost consistent effects on the onset and severity of overactive bladder.

      Conclusion

      Regular marijuana use may increase the risk of overactive bladder. Our data do not support the evidence for the use of cannabinoids in the medical treatment of patients with overactive bladder, especially given the thorny health problems caused by marijuana.

      Keywords

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