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Superior Vena Cava Syndrome as Sequelae of Novel Hodgkin Lymphoma

Published:February 21, 2022DOI:https://doi.org/10.1016/j.amjmed.2022.01.045
      The prevalence of superior vena cava syndrome has been estimated to be around 15,000 people in the United States each year, with an incidence of 1 in 650 to 1 in 3100 patients.
      • Wilson LD
      • Detterbeck FC
      • Yahalom J
      Superior vena cava syndrome with malignant causes.
      It was first described by William Hunter in 1757 as a complication of a saccular aortic aneurysm.
      • Hunter W.
      The history of an aneurysm of the aorta with some remarks on aneurysms in general.
      Superior vena cava obstruction often impairs blood flow through the superior vena cava, resulting in a collection of signs and symptoms that together constitute superior vena cava syndrome. Around 50 years ago, infectious causes, especially syphilitic aortic aneurysm and tuberculosis, accounted for the majority of cases of superior vena cava syndrome. These causes are rare now, and mediastinal malignancies account for more than 90% of current super vena cava syndrome cases, predominantly lung bronchogenic carcinomas, both small and non-small-cell lung cancer. The most common malignant causes are non-small-cell lung cancer (approximately 50% of patients), small-cell lung cancer (approximately 25% of patients), and lymphoma and metastatic lesions (each approximately 10% of patients).
      • Yellin A
      • Rosen A
      • Reichert N
      • Lieberman Y
      Superior vena cava syndrome.
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