Abstract
The definition of severe aortic stenosis has undergone significant change casting
a wider net to avoid missing patients who could benefit from valve replacement. The
presence or absence of symptoms remains the key decision-making element; however,
individuals presently undergoing evaluation are older, more likely asymptomatic, and
have lower gradients. Due to numerous potential measurement errors, attention to detail
when performing diagnostic testing and understanding their limitations are necessary
to render appropriate treatment. Exercise testing adds useful information for individuals
with severe aortic stenosis felt to be asymptomatic. Dobutamine echocardiography,
in low flow-low gradient aortic stenosis, distinguishes between a myopathic and valvular
cause of left ventricular dysfunction. Evaluation of patients when normotensive minimizes
measurement errors. The amount of aortic valve calcification adds useful information
when the degree of aortic stenosis is uncertain. A good history and physical integrated
with high-quality imaging data allows for appropriate clinical treatment decisions
for patients with aortic stenosis. The goal is simultaneously to provide aortic valve
replacement for patients in need while avoiding overdiagnosis and performance of unnecessary
procedures.
Keywords
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References
- Transcatheter versus surgical aortic-valve replacement in high-risk individuals.N Engl J Med. 2011; 364: 2187-2198
- Transcatheter or surgical aortic-valve replacement in intermediate-risk patients.N Engl J Med. 2016; 37: 1609-1620
- Transcatheter aortic valve replacement with a balloon-expandable valve in low-risk patients.N Engl J Med. 2019; 380: 1695-1705
- STS-ACC TVT registry of transcatheter aortic valve replacement.J Am Coll Cardiol. 2020; 76: 2492-2516
- Valvular aortic stenosis: disease severity and timing of intervention.J Am Coll Cardiol. 2006; 47: 2141-2151
- Clinical profile and natural history of nonsurgically managed patients with severe aortic stenosis.Ann Thorac Surg. 2006; 82: 2111-2115
- A prospective survey of patients with valvular heart disease in Europe: the euro heart survey on valvular heart disease.Eur Heart J. 2003; 24: 1231-1243
- With great power comes great responsibility.Quality Magazine. April 16, 2018; (Available at) (Accessed January 4, 2002)
- Aortic stenosis.Am J Cardiol. 1958; 1: 553-571
- Aortic stenosis.Circulation. 1968; 38: 61-67
- ACC/AHA guidelines for the management of patients with valvular heart disease: executive summary. A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on management of patients with valvular heart disease).Circulation. 1998; 98: 1949-1984
- 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease. A report of the American College of Cardiology/American Heart Association task force on practice guidelines.Circulation. 2008; 118: e523-e661
- AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.Circulation. 2014; 129: 2440-2492
- Recommendations of the echocardiographic assessment of aortic valve stenosis: a focused update from the European association of cardiovascular imaging and the American society of echocardiography.J Am Soc Echocardiogr. 2017; 30: 372-392
- How should very severe aortic stenosis be defined in asymptomatic individuals.J Am Heart Assoc. 2019; 8e011724
- Physiology in Health and Disease.Lea & Febiger, Philadelphia, PA1934
- The movement of aortic and pulmonary valves studied post mortem by colour cinematography.Br Heart J. 1952; 14: 42-46
- A postmortem cinephotographic study of valve action.Br Heart J. 1955; 17: 56-61
- Hydraulic formula for calculation of the area of the stenotic mitral valve, other cardiac valves, and central circulatory shunts. I.Am Heart J. 1951; 41: 1-29
- Prediction of the severity of aortic stenosis by Doppler aortic valve area determination; prospective Doppler catheterization correlation in 100 patients.J Am Coll Cardiol. 1988; 11: 1227-1234
- Doppler echocardiographic measurement of aortic valve area in aortic stenosis. A noninvasive application of the Gorlin formula.J Am Coll Cardiol. 1986; 8: 1059-1065
- Noninvasive assessment of valve area in patients with aortic stenosis.J Am Coll Cardiol. 1986; 7: 501-508
- Determination of the stenotic aortic valve area in adults using Doppler echocardiography.J Am Coll Cardiol. 1986; 7: 509-517
- What do you mean by aortic valve area: geometric orifice area, effective orifice area, or Gorlin area?.J Heart Valve Dis. 2006; 15: 601-608
- Determination of variation between Fick and indicator dilution estimates of cardiac output during diagnostic catheterization.J Lab Clin Med. 1976; 87: 568-576
- Advances in the hemodynamic assessment of stenotic cardiac valves.J Am Coll Cardiol. 1987; 10: 912-919
- Importance of pressure recovery for the assessment of aortic stenosis by Doppler ultrasound.Circulation. 1996; 94: 1934-1940
- Accurate assessment of aortic stenosis. A review of diagnostic modalities and hemodynamics.Circulation. 2014; 129: 244-253
- 2020 ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice.Circulation. 2021; 143: e72-227
- 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association of Cardio-Thoracic Surgery (EACTS).Eur Heart J. 2021; 60: 727-800
- Aortic stenosis.N Engl J Med. 2002; 346: 677-682
- 2017 ESC/ECATS guidelines for the management of valvular heart disease.Eur Heart J. 2017; 38: 2739-2791
- Should we forget about valve area when assessing aortic stenosis?.Heart. 2019; 105: 1-2
- Calculations of cardiac valve stenosis: restoring an old concept for advanced applications.J Am Coll Cardiol. 1987; 10: 920-922
- Hydraulic estimation of stenotic orifice area: a correction of the Gorlin formula.Circulation. 1985; 71: 1170-1178
- Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic and exercise predictors of outcome.Circulation. 1997; 95: 2262-2270
- Accurate noninvasive quantification of stenotic aortic valve area by Doppler echocardiography.Circulation. 1986; 73: 452-459
- Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.Heart. 2014; 100: 1946-1953
- Predictors of outcomes in severe, asymptomatic aortic stenosis.N Engl J Med. 2000; 346: 611-617
- Echocardiographic aortic valve calcification and outcomes in woman and men with aortic stenosis.Heart. 2017; 103: 1619-1624
- Computed tomography aortic valve calcium scoring in patients with aortic stenosis.Circ Cardiovasc Imaging. 2018; 11e007146
- Evaluation and clinical implications of aortic valve calcification measured by electron beam computed tomography.Circulation. 2004; 110: 356-362
- How does the heart respond to aortic stenosis. Let me count the ways.Circ Cardiovasc Imaging. 2013; 6: 858-860
- Aortic-valve stenosis- From patients at risk to severe valve obstruction.N Engl J Med. 2014; 371: 744-756
- Severe aortic stenosis in patients 60 years of age or older: left ventricular function and 10-year survival after valve replacement.Circulation. 1981; 64: II184-II188
- The effect of aortic valve replacement on survival.Circulation. 1982; 66: 1105-1110
- Prognostic value of aortic valve area by doppler echocardiography in patients with severe asymptomatic aortic stenosis.J Am Heart Assoc. 2016; 5e003146
- Prognostic impact of aortic valve area in conservatively managed patients with asymptomatic severe aortic stenosis with preserved ejection fraction.J Am Heart Assoc. 2019; 8e010198
- Natural history, diagnostic approaches and therapeutic strategies for patients with asymptomatic severe aortic stenosis.J Am Coll Cardiol. 2016; 67: 2263-2268
- Early surgery or conservative care for asymptomatic aortic stenosis.N Engl J Med. 2020; 382: 111-119
- Timing of intervention in aortic stenosis.N Engl J Med. 2020; 382: 191-193
- Low gradient aortic stenosis.Eur Heart J. 2016; 37: 2645-2657
- Aortic stenosis with severe left ventricular dysfunction and low transvalvular pressure gradients: risk stratification by low -dose dobutamine echocardiography.J Am Coll Cardiol. 2001; 37: 2101-2107
- Projected valve area at normal flow rate improves the assessment of stenosis severity in patients with low-flow, low-gradient aortic stenosis: the multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) study.Circulation. 2006; 113: 711-721
- Aortic valve replacement should be operated on before symptom onset.Circulation. 2012; 126: 112-117
- Use of routinely captured echocardiographic data in the diagnosis of severe aortic stenosis.Heart. 2019; 105: 112-116
- The lost art of clinical skills.Am J Med. 2007; 20: 374-378
- Overdiagnosis and overtreatment: how to deal with too much medicine.J Family Med Prim Care. 2020; 9: 3815-3819
- Preventing overdiagnosis: how to stop harming the healthy.BMJ. 2012; 344: e3502
- The high cost of unnecessary care.JAMA. 2017; 318: 1748-1749
Article Info
Publication History
Published online: December 30, 2021
Footnotes
Funding: None.
Conflicts of Interest: None.
Authorship: All authors had access to the data and a role in writing this manuscript.
Identification
Copyright
© 2022 Published by Elsevier Inc.