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Less is More: Pseudohyponatremia in Multiple Myeloma

Published:October 13, 2021DOI:https://doi.org/10.1016/j.amjmed.2021.09.017
      A 65-year-old gentleman visited his primary care provider with mechanical back pain in the absence of trauma. Previously active, he experienced reduced effort tolerance and required assistance in daily activities gradually over a period of 2 years, coupled with a significant weight loss (7% in 1 month). He has a history of diabetes mellitus, dyslipidemia, and chronic obstructive pulmonary disease. Initial investigations revealed hyponatremia: he was referred to the hospital for suspected syndrome of inappropriate antidiuretic hormone secretion (SIADH).
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