Advertisement

Paraneoplastic Neurologic Syndrome in Ewing Sarcoma

      A 30-year-old previously healthy man presented with acute-onset diplopia for 1 month, along with vertigo. A day prior to symptom onset, he also reported mid-back pain radiating to the right abdomen, and erectile dysfunction. Two weeks after symptom onset, he developed hypersensitivity in his feet, an urge to move his legs, and intermittent numbness in the groin with constipation and urinary hesitancy. The patient subsequently saw a neurologist, who diagnosed him with restless leg syndrome that improved with pramipexole. Outside-hospital brain magnetic resonance imaging showed no abnormalities. Additional spinal imaging was planned but, due to delays, he presented to us for evaluation.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Van Mater D
        • Wagner L
        Management of recurrent Ewing sarcoma: challenges and approaches.
        Onco Targets Ther. 2019; 12: 2279-2288
        • Pelosof LC
        • Gerber DE
        Paraneoplastic syndromes: an approach to diagnosis and treatment.
        Mayo Clin Proc. 2010; 85: 838-854
        • Tiwary AK
        • Greco B
        • Richardson MW
        Ectopic ACTH syndrome in a child with abdominal Ewing sarcoma: a rare paraneoplastic phenomenon.
        J Pediatr Hematol Oncol. 2020; 42: e668-e669
        • Honnorat J
        • Antoine JC
        Paraneoplastic neurological syndromes.
        Orphanet J Rare Dis. 2007; 2: 22