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Clinical Communication to the Editor| Volume 134, ISSUE 8, e447-e448, August 01, 2021

Excipient Hypersensitivity Masquerading as Multidrug Allergy

Published:March 30, 2021DOI:https://doi.org/10.1016/j.amjmed.2021.02.015
Excipient Hypersensitivity Masquerading as Multidrug Allergy
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      Drug allergy to excipients remains underappreciated and frequently leads to inappropriate medication discontinuation.
      • Reker D
      • Blum SM
      • Steiger C
      • et al.
      “Inactive” ingredients in oral medications.
      Sci Transl Med. 2019; 11: eaau6753https://doi.org/10.1126/scitranslmed.aau6753
      Here, we report a patient with multidrug allergy, which was subsequently determined to be due to hypersensitivity to an excipient common to those medications’ specific formulations.
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      References

        • Reker D
        • Blum SM
        • Steiger C
        • et al.
        “Inactive” ingredients in oral medications.
        Sci Transl Med. 2019; 11: eaau6753https://doi.org/10.1126/scitranslmed.aau6753
        View in Article

      2. Bristol-Myers Squib. Coumadin tablets (warfarin sodium tablets, USP) Crystalline. Available at: http://packageinserts.bms.com/pi/pi_coumadin.pdf. Accessed December 18, 2020.

        View in Article

      3. Mylan Pharmaceuticals Inc. Ciprofloxacin (ciprofloxacin tablet, film coated, extended release). Available at: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b92f9206-325e-4454-9518-4f7464b23f47. Accessed December 20, 2020.

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      4. Procter & Gamble Pharmaceuticals. Macrodantin (nitrofurantoin, macrocrystalline capsule). Available at: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ec86b651-d77d-4a42-b493-24244456b3f6&type=display. Accessed December 20, 2020.

        View in Article

      Article Info

      Publication History

      Published online: March 30, 2021

      Footnotes

      Funding: None.

      Conflicts of Interest: None.

      Authorship: All authors had access to the data and a role in writing this manuscript.

      Identification

      DOI: https://doi.org/10.1016/j.amjmed.2021.02.015

      Copyright

      © 2021 Elsevier Inc. All rights reserved.

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