Acquired Thrombotic Thrombocytopenic Purpura Associated with Acute Hepatitis A Infection

Published:December 11, 2020DOI:
      A 35-year-old man with no significant medical history presented with abdominal pain, vomiting, jaundice, dark-colored urine, and hematochezia. He denied confusion, easy bruising, and significant alcohol intake but did recall an episode of “food poisoning” after eating a fast-food taco 3 weeks earlier.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Joly BS
        • Coppo P
        • Veyradier A
        Thrombotic thrombocytopenic purpura.
        Blood. 2017; 129: 2836-2846
        • Bendapudi PK
        • Hurwitz S
        • Fry A
        • et al.
        Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study.
        Lancet Haematol. 2017; 4: e157-e164
        • George JN
        The importance of clinical judgment for the diagnosis of thrombotic thrombocytopenic purpura.
        Transfusion. 2017; 57: 2558-2561
        • Wynick C
        • Britto J
        • Sawler D
        • et al.
        Validation of the plasmic score for predicting ADAMTS13 activity < 10% in patients admitted to hospitals in Alberta with suspected thrombotic thrombocytopenic purpura.
        Blood. 2019; 134: 2379
        • Gangireddy M
        • Shrimanker I
        • Saintelia S
        • Nookala VK
        Active hepatitis C leading to refractory thrombotic thrombocytopenic purpura – a dubious association and the challenges faced in management.
        Cureus. 2019; 11