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Glucocorticoid-Induced Hypocalcemia in a Patient with Established Hypoparathyroidism

  • Michael C. Onyema
    Correspondence
    Requests for reprints should be addressed to Michael Onyema, MBBS, Department of Endocrinology, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
    Affiliations
    Department of Endocrinology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK
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  • Jessica Kearney
    Affiliations
    Department of Endocrinology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK
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  • Georgios K. Dimitriadis
    Affiliations
    Department of Endocrinology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK

    Department of Obesity, Immunometabolism and Diabetes, School of Life Course Sciences, Kings College London, UK

    Division of Translational and Experimental Medicine – Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK
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Published:December 11, 2020DOI:https://doi.org/10.1016/j.amjmed.2020.10.040
      Glucocorticoids are known to affect calcium balance but are not thought to cause clinically significant hypocalcemia. This case adds to a list of isolated reports noting significant hypocalcemia developing post administration of glucocorticoids in a patient with known hypoparathyroidism, postulating parathyroid hormone deficiency as a risk factor of decompensated calcium homeostasis.
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      References

        • Raisz LG
        • Lukert BP
        Glucocorticoid-induced osteoporosis: pathogenesis, prevention and treatment.
        J Bone Miner Metab. 1990; 112: 352-364
        • Lee GS
        • Choi KC
        • Jeung EB
        Glucocorticoids differentially regulate expression of duodenal and renal calbindin-D9k through glucocorticoid receptor-mediated pathway in mouse model.
        Am J Physiol Endocrinol Metab. 2006; 290: E299-E307
        • Rubin MR
        • Bilezikian JP
        Clinical review 151: the role of parathyroid hormone in the pathogenesis of glucocorticoid-induced osteoporosis: a re-examination of the evidence.
        J Clin Endocrinol Metab. 2002; 87: 4033-4041
        • Gennari C
        Differential effect of glucocorticoids on calcium absorption and bone mass.
        Br J Rheumatol. 1993; 32: 11-14
        • Handa R
        • Wali JP
        • Singh RT
        • et al.
        Corticosteroids precipitating hypocalcemic encephalopathy in hypoparathyroidism.
        Ann Emerg Med. 1995; 26: 241-242
        • Vardi P
        • Benderly A
        • Etzioni A
        • et al.
        Hypocalcaemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3.
        Eur J Pediatr. 1985; 144: 280-282
        • Kahn A
        • Snapper I
        • Drucker A
        Corticosteroid-induced tetany in latent hypoparathyroidism.
        Arch Intern Med. 1964; 114: 434-438
        • Oikonomou D
        • Laina A
        • Xydaki A
        • Christopoulos C
        Steroid-induced hypocalcaemia with tetany in a patient with hypoparathyroidism.
        BMJ Case Reports. 2014; 2014 (bcr2014207562)