Advertisement

Impact of Coffee Consumption on Physiological Markers of Cardiovascular Risk: A Systematic Review

Published:October 29, 2020DOI:https://doi.org/10.1016/j.amjmed.2020.09.036

      Abstract

      Background

      Coffee is one of the most widely consumed beverages globally. A substantial number of observational data suggest an inverse relationship between coffee consumption and the risk for cardiovascular disease. The basis for this association is not clear. In this review, we specifically study the impact of coffee on inflammatory biomarkers as one potential mechanistic basis for this observation. Our objective was to systematically review randomized controlled trials that examined the effects of coffee consumption on selected cardiovascular biomarkers.

      Methods

      We systematically reviewed bibliographic databases including PubMed (NCBI), Embase (Elsevier), CINAHL (EBSCO), Web of Science (Clarivate Analytics), Cochrane Central Register of Controlled Trials (EBSCO), and CAB Abstracts (Clarivate Analytics). We searched for randomized controlled trials that studied the effect of drinking coffee on inflammatory markers of cardiovascular risk.

      Results

      The search of electronic databases returned 1631 records. After removing duplicate records and ineligible studies, we examined a total of 40 full-text documents, 17 of which were eligible for further analysis. In our review, boiled coffee, in particular, appeared to raise total and low-density lipoprotein cholesterol and apolipoprotein B, but evidence suggests no similar effect for filtered coffee. One study showed a significant increase in blood interleukin 6 levels among individuals who drank caffeinated coffee, compared with individuals consuming no coffee.

      Conclusion

      Based on our systematic review of randomized controlled studies, we cannot confidently conclude that an anti-inflammatory effect of coffee is a major contributing factor to the lower all-cause mortality reported in observational studies.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. National Coffee Association (NCA). NCA national coffee data trends 2019. Available at: https://nationalcoffee.blog/2019/03/09/national-coffee-drinking-trends-2019/. Accessed December 10, 2019.

        • Gunter MJ
        • Murphy N
        • Cross AJ
        • et al.
        Coffee drinking and mortality in 10 European countries: a multinational cohort study.
        Ann Intern Med. 2017; 167: 236-247
        • van Dam RM
        • Pasman WJ
        • Verhoef P
        Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers.
        Diabetes Care. 2004; 27: 2990-2992
        • Tuomilehto J
        • Hu G
        • Bidel S
        • Lindstrom J
        • Jousilahti P
        Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women.
        JAMA. 2004; 291: 1213-1219
        • Weusten-Van der Wouw MP
        • Katan MB
        • Viani R
        • et al.
        Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes.
        J Lipid Res. 1994; 35: 721-733
        • Urgert R
        • Katan MB.
        The cholesterol-raising factor from coffee beans.
        Ann Rev Nutr. 1997; 17: 305-324
        • Kaptoge S
        • Di Angelantonio E
        • et al.
        • Emerging Risk Factors Collaboration
        C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
        Lancet. 2010; 375: 132-140
        • Wang X
        • Bao W
        • Liu J
        • et al.
        Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis.
        Diabetes Care. 2013; 36: 166-175
        • Ahola I
        • Jauhiainen M
        • Aro A
        The hypercholesterolaemic factor in boiled coffee is retained by a paper filter.
        J Intern Med. 1991; 230: 293-297
        • Aro A
        • Tuomilehto J
        • Kostiainen E
        • Uusitalo U
        • Pietinen P
        Boiled coffee increases serum low density lipoprotein concentration.
        Metabolism. 1987; 36: 1027-1030
        • Bak AA
        • Grobbee DE.
        The effect on serum cholesterol levels of coffee brewed by filtering or boiling.
        N Engl J Med. 1989; 321: 1432-1437
        • Burr ML
        • Limb ES
        • Sweetnam PM
        • Fehily AM
        • Amarah L
        • Hutchings A
        Instant coffee and cholesterol: a randomised controlled trial.
        Eur J Clin Nutr. 1995; 49: 779-784
        • Correa TA
        • Rogero MM
        • Mioto BM
        • et al.
        Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: a clinical trial.
        Nutrition. 2013; 29: 977-981
        • Fried RE
        • Levine DM
        • Kwiterovich PO
        • et al.
        The effect of filtered-coffee consumption on plasma lipid levels. Results of a randomized clinical trial.
        JAMA. 1992; 267: 811-815
        • van Dusseldorp M
        • Katan MB
        • van Vliet T
        • Demacker PN
        • Stalenhoef AF
        Cholesterol-raising factor from boiled coffee does not pass a paper filter.
        Arterioscler Thromb. 1991; 11: 586-593
        • De Roos B
        • Van Tol A
        • Urgert R
        • et al.
        Consumption of French-press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects.
        J Intern Med. 2000; 248: 211-216
        • Urgert R
        • Meyboom S
        • Kuilman M
        • et al.
        Comparison of effect of cafetiere and filtered coffee on serum concentrations of liver aminotransferases and lipids: six month randomised controlled trial.
        BMJ. 1996; 313: 1362-1366
        • Kempf K
        • Kolb H
        • Gartner B
        • et al.
        Cardiometabolic effects of two coffee blends differing in content for major constituents in overweight adults: a randomized controlled trial.
        Eur J Nutr. 2015; 54: 845-854
        • Rosmarin PC
        • Applegate WB
        • Somes GW
        Coffee consumption and serum lipids: a randomized, crossover clinical trial.
        Am J Med. 1990; 88: 349-356
        • Sanguigni V
        • Gallu M
        • Ruffini MP
        • Strano A
        Effects of coffee on serum cholesterol and lipoproteins: the Italian brewing method. Italian Group for the Study of Atherosclerosis and Dismetabolic Diseases, Rome II Center.
        Eur J Epidemiol. 1995; 11: 75-78
        • Shaposhnikov S
        • Hatzold T
        • Yamani NE
        • et al.
        Coffee and oxidative stress: a human intervention study.
        Eur J Nutr. 2018; 57: 533-544
        • van Dusseldorp M
        • Katan MB
        • Demacker PN
        Effect of decaffeinated versus regular coffee on serum lipoproteins. A 12-week double-blind trial.
        Am J Epidemiol. 1990; 132: 33-40
        • Wedick NM
        • Brennan AM
        • Sun Q
        • Hu FB
        • Mantzoros CS
        • van Dam RM
        Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial.
        Nutr J. 2011; 10: 93
        • Wahrburg U
        • Martin H
        • Schulte H
        • Walek T
        • Assmann G
        Effects of two kinds of decaffeinated coffee on serum lipid profiles in healthy young adults.
        Eur J Clin Nutr. 1994; 48: 172-179
        • Christensen B
        • Mosdol A
        • Retterstol L
        • Landaas S
        • Thelle DS
        Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol–a randomized controlled trial.
        Am J Clin Nutr. 2001; 74: 302-307
        • Bonaa K
        • Arnesen E
        • Thelle DS
        • Forde OH
        Coffee and cholesterol: is it all in the brewing? The Tromsø Study.
        BMJ. 1988; 297: 1103-1104
        • Arnesen E
        • Førde OH
        • Thelle DS
        Coffee and serum cholesterol.
        Br Med J (Clin Res Ed). 1984; 288: 1960
        • Forde OH
        • Knutsen SF
        • Arnesen E
        • Thelle DS
        The Tromsø heart study: coffee consumption and serum lipid concentrations in men with hypercholesterolaemia: a randomised intervention study.
        Br Med J (Clin Res Ed). 1985; 290: 893-895
        • Kubota N
        • Terauchi Y
        • Yamauchi T
        • et al.
        Disruption of adiponectin causes insulin resistance and neointimal formation.
        J Biol Chem. 2002; 277: 25863-25866
        • Nishihara T
        • Matsuda M
        • Araki H
        • et al.
        Effect of adiponectin on murine colitis induced by dextran sulfate sodium.
        Gastroenterology. 2006; 131: 853-861
        • Au Yeung SL
        • Schooling CM
        Adiponectin and coronary artery disease risk: a bi- directional Mendelian randomization study.
        Int J Cardiol. 2018; 268: 222-226