A Man with a Clot on his Platelets: Adrenal Carcinoma and Dynamic Right Ventricular Inflow Obstruction

      Adrenocortical carcinoma is a rare aggressive neoplasm that is often clinically silent until late in the disease process. A previously fit 82-year-old man presented to our service with a 4-week history of unintentional weight loss, worsening exertional dyspnea, and right-sided pleuritic chest pain. His past medical history included polymyalgia rheumatica, for which he was taking a maintenance dose of prednisolone 5 mg daily. He was a lifelong teetotaler and an ex-smoker of 30 pack-years up to the age of 50 years.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Kerkhofs T.M.A.
        • Verhoeven R.H.A.
        • van der Zwan J.M.
        • et al.
        Adrenocortical carcinoma: a population-based study on incidence and survival in the Netherlands since 1993.
        Eur J Cancer. 2013; 49: 2579-2586
        • Ng L.
        • Libertino J.M.
        Adrenocortical carcinoma: diagnosis, evaluation and treatment.
        J Urol. 2003; 169: 5-11
        • Wajchenberg B.L.
        • Albergaria Pereira M.A.
        • Medonca B.B.
        • et al.
        Adrenocortical carcinoma: clinical and laboratory observations.
        Cancer. 2000; 88: 711-736
        • Icard P.
        • Goudet P.
        • Charpenay C.
        • Andreassian B.
        • Carnaille B.
        • Chapuis Y.
        Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group.
        World J Surg. 2001; 25: 891-897