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Almost Killed by Love: A Cautionary Coital Tale

      Estimates of fatal anaphylaxis to penicillin have been reported at a rate of 0.002% among the general population, with nonfatal drug-induced anaphylaxis to this class of antibiotics ranging from 0.7% to 10%.
      • Neugut A.I.
      • Ghatak A.T.
      • Miller R.L.
      Anaphylaxis in the United States: an investigation into its epidemiology.
      Penicillins, in addition to other antibiotics, are known to concentrate at detectable levels in human semen and can be absorbed systemically by vaginal epithelium.
      • Armstrong J.R.
      • Cook F.E.
      • Robison J.R.
      Concentration of antibiotic and chemotherapeutic agents in the ejaculum.
      • Rock J.
      • Barker R.H.
      • Bacon W.B.
      Vaginal Absorption of penicillin.
      Although rare, cases of such drug exposure resulting in anaphylaxis have been described in the literature.
      • Green R.L.
      Green MA. Postcoital urticaria in a penicillin-sensitive patient. Possible seminal transfer of penicillin.
      • Burks J.H.
      • Fliegelman R.
      • Sokalski S.J.
      An unforeseen complication of home parenteral antibiotic therapy.
      We present a patient with a reported penicillin allergy who developed anaphylaxis shortly after sexual intercourse with her spouse who was receiving parenteral nafcillin for infective endocarditis.
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      References

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        Anaphylaxis in the United States: an investigation into its epidemiology.
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