Abstract
Routine moderate-intensity physical activity confers numerous cardiovascular benefits
and reduces all-cause mortality. However, the health impact of exercise doses that
exceed contemporary physical activity guidelines remains incompletely understood,
and an emerging body of literature suggests that high levels of exercise may have
the capacity to damage the cardiovascular system. This review focuses on the contemporary
controversies regarding high-dose exercise and cardiovascular morbidity and mortality.
We discuss the limitations of available studies, explore potential mechanisms that
may mediate exercise-related cardiac injury, and highlight the gaps in knowledge for
future research.
Keywords
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Article Info
Publication History
Published online: June 26, 2018
Footnotes
Funding: None.
Conflict of Interest: None.
Authorship: All authors had access to the data and a role in writing the manuscript.
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