Advertisement
Images in Dermatology| Volume 131, ISSUE 8, P922-926, August 2018

At the Root: Cutaneous Langerhans Cell Histiocytosis

      Hair loss is of deep concern to patients, mainly because of its effect on appearance. On rare occasions, however, areas of balding can signal malignancy. A 33-year-old woman was referred to our dermatology clinic because of a 15-year history of scalp eruption accompanied by intense itching and progressive hair loss. Previously, she was diagnosed with seborrheic dermatitis associated with female androgenic alopecia. She was treated with topical steroids for numerous years without improvement, except for transient relief of itching. Five years prior to her referral to our clinic, she underwent surgery for an in situ melanoma of the leg. Otherwise, her past medical history was unremarkable.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Stålemark H
        • Laurencikas E
        • Karis J
        • Gavhed D
        • Fadeel B
        • Henter JI
        Incidence of Langerhans cell histiocytosis in children: a population-based study.
        Pediatr Blood Cancer. 2008; 51: 76-81
        • Egeler RM
        • van Halteren AGS
        • Hogendoorn PCW
        • Laman JD
        • Leenen PJ
        Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage.
        Immunol Rev. 2010; 234: 213-232
        • Zhang S
        • Liu Y
        Langerhans cell histiocytosis in an adult female presenting with widespread confluent crusted papules and review of adult cases confined to skin.
        Int J Dermatol. 2017; 56: 1182-1185
        • Roider E
        • Signer C
        • Fehrenbacher B
        • et al.
        Individualized treatment approaches for Langerhans cell histiocytosis [e-pub ahead of print].
        Br J Dermatol. 2018; (accessed May 15)https://doi.org/10.1111/bjd.16171
        • Girschikofsky M
        • Arico M
        • Castillo D
        • et al.
        Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net.
        Orphanet J Rare Dis. 2013; 8: 72
        • Hancox JG
        • James AP
        • Madden C
        • Wallace CA
        • McMichael AJ
        Adult onset folliculocentric Langerhans cell histiocytosis confined to the scalp.
        Am J Dermatopathol. 2004; 26: 123-126
        • Nguyen E
        • Claar D
        • McGuinn E
        • Mast K
        • Hartley K
        • McDonagh K
        Persistence pays off: adult Langerhans cell histiocytosis.
        Am J Med. 2016; 129: e55-e59
        • Allen CE
        • Ladisch S
        • McClain KL
        How I treat Langerhans cell histiocytosis.
        Blood. 2015; 126: 26-35
        • Bernstrand C
        • Sandstedt B
        • Ahström L
        • Henter JI
        Long-term follow-up of Langerhans cell histiocytosis: 39 years’ experience at a single centre.
        Acta Paediatr. 2005; 94: 1073-1084
        • Edelbroek JR
        • Vermeer MH
        • Jansen PM
        • et al.
        Langerhans cell histiocytosis first presenting in the skin in adults: frequent association with a second haematological malignancy.
        Br J Dermatol. 2012; 167: 1287-1294