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University of Maryland Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, BaltimoreDepartment of Medicine, University of Maryland School of Medicine, Baltimore
University of Maryland Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, BaltimoreDepartment of Medicine, University of Maryland School of Medicine, Baltimore
Requests for reprints should be addressed to Jennie Y. Law, MD, University of Maryland School of Medicine, Marlene & Stewart Greenebaum Comprehensive Cancer Center, 22 South Greene Street, Room S9D15C, Baltimore, MD 21201.
University of Maryland Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, BaltimoreDepartment of Medicine, University of Maryland School of Medicine, Baltimore
A 70-year-old Caucasian woman with a medical history of chronic obstructive pulmonary
disease, hypertension, and hypothyroidism presented with progressively worsening left
ocular proptosis and eyelid swelling for 2 weeks and diplopia for 2 days. On physical
examination she had left eye ptosis, proptosis, and limited upward, left, and right
lateral extraocular movement (Figure, A). Hemoglobin was 9.3 g/dL, white blood cell count 16.1 K/µL, platelet count 78 K/µL,
and lactate dehydrogenase 1681 U/L. Peripheral blood smear was reviewed (Figure, B). Computed tomographic angiography of the head showed a retro-orbital mass. A whole-body
positron emission tomography scan showed soft tissue lesions in the left posterolateral
chest wall, iliac fossa, and sacral and presacral regions, and a left extraconal mass,
all with increased fluorodeoxyglucose uptake (Figure, C). Bone marrow and chest wall mass were biopsied (Figure, D).
Figure(A) Unilateral proptosis and impaired left eye upward gaze. (B) Peripheral blood smear. (C) Positron emission tomography scan with increased fluorodeoxyglucose uptake in left
extraconal mass viewed on coronal plane. (D) Bone marrow aspirate.
Acute myeloid leukemia with t(8;21)(q22;q22) manifesting as granulocytic sarcomas in the rhinopharynx and external acoustic meatus at relapse after high-dose cytarabine: case report and review of the literature.
Authorship: Conception and design: FEC, MRB, and JYL. Provision of study materials: FEC, YZ, PM, and ZNS. Collection and assembly of data: FEC. Data analysis and interpretation, manuscript writing, final approval of manuscript, accountability for all aspects of the work: all authors.
