Diagnostic Dilemma| Volume 131, ISSUE 8, P916-917, August 2018

Blood Is Thicker: Hyperviscosity Syndrome

      Pain, presumably related to a previous injury, was the patient's main concern, but in fact, she had a serious complication of an as yet undiagnosed disease. A 49-year-old woman presented to the emergency department with persistent chest pain and new back pain. Three months earlier, she had a mechanical fall from standing height that resulted in fractures of her left seventh, eighth, and ninth ribs. Left-sided chest pain persisted, and she developed nontraumatic lower back pain that progressed in severity, prompting her to seek care.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Mehta J.
        • Singhal S.
        Hyperviscosity syndrome in plasma cell dyscrasias.
        Semin Thromb Hemost. 2003; 29: 467-471
        • Kim W.
        • Kweon E.
        Images in clinical medicine: hyperviscosity-related retinopathy in Waldenström's macroglobulinemia.
        N Engl J Med. 2016; 374: 73
        • Rosenson R.S.
        • McCormick A.
        • Uretz E.F.
        Distribution of blood viscosity values and biochemical correlates in healthy adults.
        Clin Chem. 1996; 42: 1189-1195
        • Höffkes H.G.
        • Heemann U.W.
        • Teschendorf C.
        • Uppenkamp M.
        • Philipp T.
        Hyperviscosity syndrome: efficacy and comparison of plasma exchange by plasma separation and cascade filtration in patients with immunocytoma of Waldenström's type.
        Clin Nephrol. 1995; 43: 335-338