Gradually Transformed: Parry–Romberg Syndrome

      Headaches commonly compel patients to seek medical attention. Migraine, tension headache, cluster headaches, rebound headaches from overuse of medication, headaches that occur as an adverse reaction to medication, and those associated with infection are typically included in the differential diagnosis, but sometimes, a rarer entity is encountered. This was true for a 44-year-old farmer from rural Honduras.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Parry C.H.
        Collections from the Unpublished Medical Writings of the Late Caleb Hillier Parry.
        Underwoods, London, UK1825: 478
        • Romberg M.H.
        • Henoch E.H.
        Krankheiten des Nervensystems (IV: Trophoneurosen). Klinische Ergebnisse.
        Albert Förstner, Berlin1846: 75-81
        • Eulenburg A.
        Hemiatrophia facialis progressiva. Lehrbuch der functionellen nervenkrankheiten auf physiologischer basis.
        Verlag von August Hirschwald, Berlin1871: 712-726
        • Zulian F.
        Scleroderma in children.
        Pediatr Clin North Am. 2005; 52: 521-545
        • Uhrhan K.
        • Rabenstein M.
        • Kobe C.
        • Drzezga A.
        • Fink G.R.
        • Burghaus L.
        Brain glucose metabolism in Parry-Romberg syndrome.
        Clin Nucl Med. 2017; 42: e251-e252
        • Tollefson M.M.
        • Witman P.M.
        En coup de sabre morphea and Parry-Romberg syndrome: a retrospective review of 54 patients.
        J Am Acad Dermatol. 2007; 56: 257-263
        • Tolkachjov S.N.
        • Patel N.G.
        • Tollefson M.M.
        Progressive hemifacial atrophy: a review.
        Orphanet J Rare Dis. 2015; 10: 39
        • Seegobin K.
        • Abdool K.
        • Ramcharan K.
        • Dyaanand H.
        • Rampersad F.
        The chronic encephalopathy of Parry Romberg syndrome and en coupe de sabre with a 31-year-history in a West Indian woman: clinical, immunologic and neuroimaging abnormalities.
        Neurol Int. 2016; 8: 6661
        • Duymaz A.
        • Karabekmez F.E.
        • Keskin M.
        • Tosun Z.
        Parry-Romberg syndrome: facial atrophy and its relationship with other regions of the body.
        Ann Plast Surg. 2009; 63: 457-461
        • Careta M.F.
        • Romiti R.
        Localized scleroderma: clinical spectrum and therapeutic update.
        An Bras Dermatol. 2015; 90: 62-73