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Skin and Nasal Involvement: Look for Sarcoidosis!

  • Thomas Radulesco
    Correspondence
    Requests for reprints should be addressed to Thomas Radulesco, MD, MSc, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Assistance Publique, Hôpitaux de Marseille, La Conception University Hospital, 147 Bd. Baille, Marseille 13005, France.
    Affiliations
    Assistance Publique Hopitaux de Marseille (APHM), Department of Oto-Rhino-Laryngology and Head and Neck Surgery, La Conception University Hospital, Marseille, France

    Centre national de la recherche scientifique (CNRS), Institut Universitaire des Systèmes Thermiques Industriels (IUSTI), Aix-Marseille Université, Marseille, France
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  • Pierre-André Jarrot
    Affiliations
    APHM, Department of Internal Medicine and Clinical Immunology, La Conception University Hospital, Marseille, France
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  • Raphael Cauchois
    Affiliations
    APHM, Department of Internal Medicine and Clinical Immunology, La Conception University Hospital, Marseille, France
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  • Nicolas Macagno
    Affiliations
    APHM, Department of Pathology, Timone Hospital, Assistance Publique Hopitaux de Marseille, Marseille, France
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  • Gilles Kaplanski
    Affiliations
    APHM, Department of Internal Medicine and Clinical Immunology, La Conception University Hospital, Marseille, France
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  • Patrick Dessi
    Affiliations
    Assistance Publique Hopitaux de Marseille (APHM), Department of Oto-Rhino-Laryngology and Head and Neck Surgery, La Conception University Hospital, Marseille, France
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  • Justin Michel
    Affiliations
    Assistance Publique Hopitaux de Marseille (APHM), Department of Oto-Rhino-Laryngology and Head and Neck Surgery, La Conception University Hospital, Marseille, France

    Centre national de la recherche scientifique (CNRS), Institut Universitaire des Systèmes Thermiques Industriels (IUSTI), Aix-Marseille Université, Marseille, France
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      Sarcoidosis is a systemic, noncaseating, granulomatous disease affecting young adults between the ages of 25 and 40 years, most often of Black origin (35.5/100,000 vs 10.9 in the White population). Although the lower respiratory tract is affected in 90% of cases, ear, nose, and throat locations are very uncommon, with a prevalence varying between 1% and 6.5%.
      • Bresnitz E.
      • Strom B.
      Epidemiology of sarcoidosis.
      In addition, ear, nose, and throat manifestations are nonspecific, and may be difficult to differentiate from other granulomatous diseases such as actinomycosis, aspergillosis, antineutrophil cytoplasmic antibody-associated vasculitis and tuberculosis, thus, frequently giving rise to misdiagnosis and delayed treatment.
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