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Sweet's Syndrome Mimicking Anti-Neutrophil Cytoplasmic Antibodies–Associated Vasculitis

Published:January 16, 2018DOI:https://doi.org/10.1016/j.amjmed.2017.12.033
      Sweet's syndrome is a rare neutrophilic skin disorder. The antibodies against neutrophil cytoplasmic antigens are called anti-neutrophil cytoplasmic antibodies (ANCAs). Positivity for ANCA has been reported in some nonvasculitic inflammatory disorders, including Sweet's syndrome.
      • Merkel P.A.
      • Polisson R.P.
      • Chang Y.
      • Skates S.J.
      • Niles J.L.
      Prevalence of antineutrophil cytoplasmic antibodies in a large inception cohort of patients with connective tissue disease.
      • Kemmett D.
      • Harrison D.J.
      • Hunter J.A.
      Antibodies to neutrophil cytoplasmic antigens: serologic marker for Sweet's syndrome.
      Here we report a case of myeloperoxidase (MPO)-ANCA– and (proteinase 3) (PR3)-ANCA–positive Sweet's syndrome presenting unusual and severe purpuras.
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