Intracranial Calcification Due to Hypoparathyroidism

Published:January 16, 2018DOI:
      A 70-year-old Japanese man with a history of idiopathic hypoparathyroidism presented to the Emergency Department of our hospital owing to weakness in his right leg. Although his primary care doctor had prescribed activated vitamin D analogues, his serum calcium level was slightly low at 8.0 mg/dL. Owing to suspicions of stroke, he underwent radiographic imaging of the head. Computed tomography revealed bilateral and symmetrical calcifications in the basal ganglia, cerebellum, and at the gray-white junction in the axial image and the sagittal image (Figure). These findings were consistent with those of long-term hypoparathyroidism. Diffusion-weighted magnetic resonance imaging revealed a high-intensity area in his left deep white matter of the brain, which was consistent with acute cerebral infarction. He received inpatient treatment for acute cerebral infarction and was discharged with functional recovery.
      FigureComputed tomography of the head showing bilateral and symmetrical calcifications in basal ganglia in the axial image (A), and in the cerebellum and at the gray-white junction in the sagittal image (B).
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • John D.R.
        • Suthar P.P.
        Radiological features of long-standing hypoparathyroidism.
        Pol J Radiol. 2016; 81: 42-45
        • Mejdoubi M.
        • Zegermann T.
        Neurological picture. Extensive brain calcification in idiopathic hypoparathyroidism.
        J Neurol Neurosurg Psychiatry. 2006; 77: 1328
        • Koller W.C.
        • Cochran J.W.
        • Klawans H.L.
        Calcification of the basal ganglia: computerized tomography and clinical correlation.
        Neurology. 1979; 29: 328-333