Abstract
The epidemiologic data associating infection and inflammation with increased risk
of cardiovascular disease is well established. Patients with chronically upregulated
inflammatory pathways, such as those with HIV and inflammatory joint diseases, often
have a risk of future cardiovascular risk that is similar to or higher than patients
with diabetes. Thus, it is of heightened importance for clinicians to consider the
cardiovascular risk of patients with these conditions. HIV and inflammatory joint
diseases are archetypal examples of how inflammatory disorders contribute to vascular
disease and provide illustrative lessons that can be leveraged in the prevention of
cardiovascular disease. Managing chronic inflammatory diseases calls for a multifaceted
approach to evaluation and treatment of suboptimal lifestyle habits, accurate estimation
of cardiovascular disease risk with potential upwards recalibration due to chronic
inflammation, and more intensive treatment of risk factors because current tools often
underestimate the risk in this population. This approach is further supported by the
recently published CANTOS trial demonstrating that reducing inflammation can serve
as a therapeutic target among persons with residual inflammatory risk for cardiovascular
disease.
Keywords
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Article info
Publication history
Published online: December 18, 2017
Footnotes
Funding: None.
Conflicts of Interest: None.
Authorship: All authors contributed to writing the manuscript and reviewed the final version before submission. All authors had access to the data and a role in writing this manuscript.
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