Clinical Research Study| Volume 131, ISSUE 4, P408-414, April 2018

Marijuana Use and Renal Function Among US Adults

Published:December 29, 2017DOI:



      In recent years, the number of states that have legalized medical marijuana or retail sales has increased, bringing potential changes of marijuana use pattern among the general population. However, health effects of acute and chronic marijuana use on many relevant health outcomes, including renal function, remain largely unexamined. In this study, we aimed to assess the association between recent and past marijuana use and renal function.


      We conducted a cross-sectional study among 13,995 US adults aged 18 to 59 years in the National Health and Nutrition Examination Survey from 2007 to 2014. We examined associations between marijuana use and serum creatinine concentration, estimated glomerular filtration rate (eGFR), and odds of having stage 2 or greater chronic kidney disease using weighted multivariable linear regression.


      In the study population, 6483 were never users, 5499 were past users, and 2013 were current users. Marijuana use did not have a significant association with serum creatinine, eGFR, or odds of having stage 2 or greater chronic kidney disease. Serum creatinine and eGFR had an increasing trend comparing past and current users with never users that did not reach statistical significance. All associations remained unchanged in the sensitivity analysis restricted to people without cardiovascular disease.


      We did not observe any clinically significant association between current or past self-reported marijuana use and measures of kidney function.


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        • Han B.H.
        • Sherman S.
        • Mauro P.M.
        • Martins S.S.
        • Rotenberg J.
        • Palamar J.J.
        Demographic trends among older cannabis users in the United States, 2006-13.
        Addiction. 2017; 112: 516-525
        • Center for Behavioral Health Statistics and Quality
        Key substance use and mental health indicators in the United States: Results from the 2015 National Survey on Drug Use and Health.
        (Available at:)
        • National Academies of Sciences, Engineering, and Medicine
        The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research.
        The National Academies Press, Washington, DC2017
        • Mittleman M.A.
        • Lewis R.A.
        • Maclure M.
        • Sherwood J.B.
        • Muller J.E.
        Triggering myocardial infarction by marijuana.
        Circulation. 2001; 103: 2805-2809
        • Papatheodorou S.I.
        • Buettner H.
        • Rice M.B.
        • Mittleman M.A.
        Recent marijuana use and associations with exhaled nitric oxide and pulmonary function in adults in the United States.
        Chest. 2016; 149: 1428-1435
        • Wang X.
        • Derakhshandeh R.
        • Liu J.
        • et al.
        One minute of marijuana secondhand smoke exposure substantially impairs vascular endothelial function.
        J Am Heart Assoc. 2016; 5: e003858
        • Vidot D.C.
        • Prado G.
        • Hlaing W.M.
        • Florez H.J.
        • Arheart K.L.
        • Messiah S.E.
        Metabolic syndrome among marijuana users in the United States: an analysis of National Health and Nutrition Examination Survey data.
        Am J Med. 2016; 129: 173-179
        • Penner E.A.
        • Buettner H.
        • Mittleman M.A.
        The impact of marijuana use on glucose, insulin, and insulin resistance among US adults.
        Am J Med. 2013; 126: 583-589
        • Lecru L.
        • Desterke C.
        • Grassin-Delyle S.
        • et al.
        Cannabinoid receptor 1 is a major mediator of renal fibrosis.
        Kidney Int. 2015; 88: 72-84
        • Singla S.
        • Sachdeva R.
        • Mehta J.L.
        Cannabinoids and atherosclerotic coronary heart disease.
        Clin Cardiol. 2012; 35: 329-335
        • Slavic S.
        • Lauer D.
        • Sommerfeld M.
        • et al.
        Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome.
        J Mol Med. 2013; 91: 811-823
        • Larrinaga G.
        • Varona A.
        • Perez I.
        • et al.
        Expression of cannabinoid receptors in human kidney.
        Histol Histopathol. 2010; 25: 1133-1138
        • Mehta A.J.
        • Zanobetti A.
        • Bind M.A.
        • et al.
        Long-term exposure to ambient fine particulate matter and renal function in older men: the veterans administration normative aging study.
        Environ Health Perspect. 2016; 124: 1353-1360
        • Xu X.
        • Wang G.
        • Chen N.
        • et al.
        Long-term exposure to air pollution and increased risk of membranous nephropathy in China.
        J Am Soc Nephrol. 2016; 27: 3739-3746
        • Centers for Disease Control and Prevention
        National Health and Nutrition Examination Survey.
        (Available at:)
        Date accessed: September 16, 2017
        • Centers for Disease Control and Prevention
        National Health and Nutrition Examination Survey (NHANES): MEC laboratory procedures manual.
        (Available at:)
        • Centers for Disease Control and Prevention
        Laboratory procedures manual, analyte: urinary albumin.
        (Available at:)
        • Centers for Disease Control and Prevention
        Laboratory procedures manual, analyte: creatinine.
        (Available at:)
        • Levey A.S.
        • Stevens L.A.
        • Schmid C.H.
        • et al.
        A new equation to estimate glomerular filtration rate.
        Ann Intern Med. 2009; 150: 604-612
        • Levey A.S.
        • Coresh J.
        • Greene T.
        • et al.
        Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate.
        Ann Intern Med. 2006; 145: 247-254
        • Centers for Disease Control and Prevention
        Key concepts about age standardization.
        (Available at:)
        • Renal Association
        CKD stages.
        (Available at:)
        • National Kidney Foundation
        NKF KDOQI guidelines.
        (Available at:)
        • Schafer J.L.
        Analysis of Incomplete Multivariate Data.
        Chapman & Hall/CRC, London, UK1997
        • Shankar A.
        • Klein R.
        • Klein B.E.
        The association among smoking, heavy drinking, and chronic kidney disease.
        Am J Epidemiol. 2006; 164: 263-271
        • Bash L.D.
        • Astor B.C.
        • Coresh J.
        Risk of incident ESRD: a comprehensive look at cardiovascular risk factors and 17 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study.
        Am J Kidney Dis. 2010; 55: 31-41
        • Dulger H.
        • Donder A.
        • Sekeroglu M.R.
        • Erkoc R.
        • Ozbay B.
        Investigation of the relationship between serum levels of cotinine and the renal function in active and passive smokers.
        Ren Fail. 2011; 33: 475-479
        • Hogan S.L.
        • Vupputuri S.
        • Guo X.
        • et al.
        Association of cigarette smoking with albuminuria in the United States: the third National Health and Nutrition Examination Survey.
        Ren Fail. 2007; 29: 133-142
        • Aztatzi-Aguilar O.G.
        • Uribe-Ramirez M.
        • Narvaez-Morales J.
        • De Vizcaya-Ruiz A.
        • Barbier O.
        Early kidney damage induced by subchronic exposure to PM2.5 in rats.
        Part Fibre Toxicol. 2016; 13: 68
        • Liu B.
        • Wang D.
        • Hao Z.
        • et al.
        Reduction in estimated glomerular filtration rate (eGFR) results in an increased risk of spontaneous hemorrhagic transformation in patients with large-artery atherosclerosis stroke.
        Curr Neurovasc Res. 2016; 13: 75-81