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Reninoma: A Rare Cause of Curable Hypertension and Hypokalemia

      A 30-year-old woman presented with uncontrolled hypertension, despite metoprolol 200 mg and perindopril 10 mg. Her medical history included hypertension for the past 5 years, a trauma, an eye operation, and gestational diabetes. The patient complained of headaches, palpitations, polydipsia, polyuria, and panic attacks. She denied drug abuse and had stopped oral contraceptives. Salt intake was moderate, and body mass index was 26 kg/m2. The family was positive for hypertension. Office blood pressure (BP) was 172/130 mm Hg without significant left–right differences. Her 24-hour BP averaged 123/80 mm Hg, with a nocturnal fall of 9%. Renal function was normal, and hypokalemia (3.0 mmol/L) was resistant to 3600 mg potassium daily. Proteinuria, left ventricular hypertrophy, and hypertensive retinopathy were absent. Medication was switched to doxazosine 4 mg and nifedipine retard 30 mg to test for secondary hypertension.
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      References

        • Robertson P.W.
        • Klidjian A.
        • Harding L.K.
        • Walters G.
        • Lee M.R.
        • Robb-Smith A.H.
        Hypertension due to a renin-secreting renal tumour.
        Am J Med. 1967; 43: 963-976
        • Trnka P.
        • Orellana L.
        • Walsh M.
        • Pool L.
        • Borzi P.
        Reninoma: an uncommon cause of renin-mediated hypertension.
        Front Pediatr. 2014; 2: 89
        • Wong L.
        • Hsu T.H.
        • Perlroth M.G.
        • Hofmann L.V.
        • Haynes C.M.
        • Katznelson L.
        Reninoma: case report and literature review.
        J Hypertens. 2008; 26: 368-373
        • Osawa S.
        • Hosokawa Y.
        • Soda T.
        • et al.
        Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling.
        Intern Med. 2013; 52: 1937-1942
        • Warshaw B.L.
        • Anand S.K.
        • Olson D.L.
        • Grushkin C.M.
        • Heuser E.T.
        • Lieberman E.
        Hypertension secondary to a renin-producing juxtaglomerular cell tumor.
        J Pediatr. 1979; 94: 247-250