Hemochromatosis Unveiled by Testosterone Replacement in a Man with Hypogonadism

  • Aidar R. Gosmanov
    Requests for reprints should be addressed to Aidar R. Gosmanov, MD, PhD, Department of Medicine, Endocrinology Section, Stratton VAMC, 113 Holland Avenue, Room A738, Albany, NY 12208.
    Endocrinology Section, Stratton VA Medical Center, Albany, NY
    Search for articles by this author
      Hemochromatosis is a primary iron overload syndrome that, if untreated, can result in end-organ dysfunction, including hypogonadotropic hypogonadism.
      • Yen A.W.
      • Fancher T.L.
      • Bowlus C.L.
      Revisiting hereditary hemochromatosis: current concepts and progress.
      Here we describe a case of missed diagnosis of hemochromatosis that was unmasked by testosterone therapy in a man with hypogonadism.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Yen A.W.
        • Fancher T.L.
        • Bowlus C.L.
        Revisiting hereditary hemochromatosis: current concepts and progress.
        Am J Med. 2006; 119: 391-399
        • Adams P.C.
        • Reboussin D.M.
        • Barton J.C.
        • et al.
        Hemochromatosis and iron-overload screening in a racially diverse population.
        N Engl J Med. 2005; 352: 1769-1778
        • Allen K.J.
        • Gurrin L.C.
        • Constantine C.C.
        • et al.
        Iron-overload-related disease in HFE hereditary hemochromatosis.
        N Engl J Med. 2008; 358: 221-230
        • Coviello A.D.
        • Kaplan B.
        • Lakshman K.M.
        • et al.
        Effects of graded doses of testosterone on erythropoiesis in healthy young and older men.
        J Clin Endocrinol Metab. 2008; 93: 914-919
        • Bhasin S.
        • Cunningham G.R.
        • Hayes F.J.
        • et al.
        Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.
        J Clin Endocrinol Metab. 2010; 95: 2536-2559