Abstract
Background
Methods
Results
Conclusions
Keywords
- •Cooking with a blend of unrefined cold-pressed sesame oil and physically refined rice bran oil effectively reduced hyperglycemia. However, a combination of sesame oil blend and antidiabetic medication yielded even more promising results to reduce hyperglycemia in patients with type 2 diabetes mellitus.
- •Use of sesame oil blend as cooking medium for 8 weeks seemed to make a difference on lipid levels by reducing total cholesterol, triglycerides, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol.
- Danaei G.
- Finucane M.M.
- Lu Y.
- et al.
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants.
- Patel P.S.
- Sharp S.J.
- Jansen E.
- et al.
Materials and Methods
Subjects
Study Design

Methods
Anthropometric and Biochemical Determinations
Data Analyses
Results
Baseline Characteristics of the Study Participants
Parameters | Sesame Oil Blend | Type 2 Diabetes Mellitus Patients | ||||
---|---|---|---|---|---|---|
Normal Subjects | Type 2 Diabetes Mellitus Patients | P Value | Glibenclamide (n = 100) | Glibenclamide + Sesame Oil Blend (n = 100) | P Value | |
Study 1 | Study 2 | |||||
Age, (Y) | 32.6 ± 10.0 | 50.8 ± 11.0 | <.001 | 50.6 ± 10.6 | 49.8 ± 10.8 | .63 |
Sex, Male (%) | 55 (55%) | 46 (46%) | .2 | 61 (61%) | 55 (55%) | .39 |
Body weight, kg | 62.4 ± 9.6 | 63.3 ± 10.8 | .01 | 68.7 ± 9.4 | 68.4 ± 12.3 | .87 |
Waist:hip ratio | 0.99 ± 0.04 | 0.98 ± 0.03 | .5 | 0.96 ± 0.07 | 0.98 ± 0.11 | .17 |
BMI, kg/m2 | 23.9 ± 3.6 | 26.0 ± 4.5 | <.001 | 27.0 ± 4.3 | 26.3 ± 4.4 | .27 |
Smoking, n (%) | 3 (3%) | 4 (4%) | 1 | 5 (5%) | 11 (11%) | .19 |
Alcohol, n (%) | 0 (0%) | 0 (0%) | 2 (2%) | 12 (12%) | .01 | |
Betel nut chewing, n (%) | 0 (0%) | 3 (3%) | .25 | 1 (1%) | 8 (8%) | .03 |
Physical activity, n (%) | 100 (100%) | 87 (97%) | .25 | 71 (71%) | 77 (57%) | .06 |
Study 1: Effect of Sesame Oil Blend on Normoglycemic Subjects vs Type 2 Diabetes Mellitus Patients
Parameters | Sesame Oil Blend | Type 2 Diabetes Mellitus Patients | ||||
---|---|---|---|---|---|---|
Normal Subjects (n = 100) | Type 2 Diabetes Mellitus Patients (n = 100) | Group Period Interaction (P Value) | Glibenclamide (n = 100) | Glibenclamide + Sesame Oil Blend (n = 100) | Group Period Interaction (P value) | |
Study 1 | Study 2 | |||||
Fasting plasma glucose (mg/dL) | ||||||
0 days | 95 ± 8 | 181 ± 20 | 180 ± 18 | 184 ± 37 | ||
Week 4 | 162 ± 24 | 153 ± 14 | 150 ± 30 | |||
Week 8 | 93 ± 7 | 155 ± 21 | <.001 | 137 ± 12 | 128 ± 26 | .04 |
Postprandial plasma glucose (mg/dL) | ||||||
0 days | 121 ± 10 | 242 ± 26 | 246 ± 27 | 248 ± 37 | ||
Week 4 | 219 ± 28 | 220 ± 24 | 210 ± 41 | |||
Week 8 | 119 ± 10 | 189 ± 36 | <.001 | 175 ± 14 | 161 ± 37 | .02 |
HbA1c (%) | ||||||
0 days | 5.1 ± 0.5 | 7.3 ± 1.2 | 7.3 ± 1.2 | 7.2 ± 1.4 | ||
Week 8 | 5.0 ± 0.4 | 6.5 ± 1.0 | <.001 | 6.4 ± 1.2 | 5.6 ± 0.9 | <.001 |
Total cholesterol (mg/dL) | ||||||
0 days | 172 ± 14 | 230 ± 27 | 230 ± 31 | 231 ± 26 | ||
Week 8 | 170 ± 14 | 184 ± 16 | <.001 | 233 ± 29 | 185 ± 20 | <.001 |
Triglyceride (mg/dL) | ||||||
0 days | 148 ± 8 | 193 ± 29 | 195 ± 30 | 196 ± 34 | ||
Week 8 | 145 ± 8 | 166 ± 15 | <.001 | 198 ± 39 | 170 ± 24 | <.001 |
HDL-C (mg/dL) | ||||||
0 days | 49 ± 5.5 | 45.1 ± 4.5 | 44.8 ± 3.9 | 45.1 ± 5.6 | ||
Week 8 | 49.4 ± 5.3 | 50.9 ± 5.1 | <.001 | 44.4 ± 3.9 | 52.2 ± 6.5 | <.001 |
LDL-C (mg/dL) | ||||||
0 days | 94 ± 15 | 147 ± 28 | 146 ± 31 | 147 ± 27 | ||
Week 8 | 92 ± 15 | 100 ± 16 | <.001 | 149 ± 30 | 99 ± 20 | <.001 |
Non-HDL-C (mg/dL) | ||||||
0 days | 123 ± 16 | 185 ± 28 | 186 ± 31 | 186 ± 26 | ||
Week 8 | 121 ± 15 | 133 ± 16 | <.001 | 189 ± 29 | 133 ± 21 | <.001 |


Study 2: Additive Effect of Sesame Oil Blend in Type 2 Diabetes Mellitus Patients Receiving Glibenclamide
Discussion
Fatty Acids & Antioxidants Composition (%) | Sesame Oil | Rice Bran Oil | Sesame Oil and Rice Bran Oil Blend |
---|---|---|---|
SFA | |||
Palmitic acid | 9.31 | 20.08 | 17.92 |
Stearic acid | 5.43 | 2.41 | 3.01 |
Arachidonic acid | 0.66 | 0.52 | 0.52 |
MUFA | |||
Oleic acid | 42.91 | 42.98 | 42.97 |
PUFA | |||
Linoleic acid | 41.28 | 33.63 | 35.56 |
Linolenic acid | 0.44 | 0.39 | 0.4 |
Antioxidants | |||
Sesame lignans (%) | 1.5 | — | 0.3 |
Oryzanol (%) | — | 1 | 0.8 |
Tocopherols (mg/100 g) | 50 | 50 | 50 |
Helli B, Mowla K, Mohammadshahi M, Jalali MT. Effect of sesamin supplementation on cardiovascular risk factors in women with rheumatoid arthritis [e-pub ahead of print]. J Am Coll Nutr. 2015. http://dx.doi.org/10.1080/07315724.2015.1005198.
Acknowledgment
References
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Article Info
Publication History
Footnotes
Funding: None.
Conflict of Interest: None.
Authorship: The contributions of authors are as follows: SD: study design, general supervision of the research group, writing and critical revision of the manuscript; BC: theoretical conception and formulation of the sesame oil blend; HU: reviewing the manuscript for important intellectual content: BZ: the statistical analysis, illustration of figures, and interpretation of data; AA: edited and revised the manuscript; RS: study management, follow up patients' enrollment and data collection; SG: reviewing the manuscript.