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These errors were not made, but in reviewing our article in the light of Mbuagbaw's letter, we identified that the number of adherent patients in the text and no-text groups of one of the trials (Pop-Eleches et al)
Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders.
should be 136 and 56, respectively (not 153 and 55 as published in our article). These numerical errors were not used in deriving the estimates of improved adherence in our article; the correct numbers were used, so that the figure in our article and the overall results are correct. The figure is reproduced here (Figure) with the correct numbers from the trial by Pop-Eleches et al.
Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders.
Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders.
as a 1-way trial when, in his view, it should have been classified as a 2-way trial. In his trial he offered patients a telephone number to call if they wished, without any obligation to respond to a text message. In 2-way trials there is a requirement that patients respond to text messaging, otherwise they would be contacted. On this basis we believe that we were correct in classifying Mbuagbaw's trial as a 1-way trial in our meta-analysis but note that even if we had not, it would not have altered our conclusion.
Mbuagbaw incorrectly states that previous meta-analyses
demonstrated the superiority of 2-way text messaging over 1-way text messaging on medication adherence. This is incorrect because the 2 methods were not compared in these articles. Our meta-analysis did this and showed that 2-way messaging is better than 1-way.
References
Wald D.S.
Butt S.
Bestwick J.P.
One-way versus two-way text messaging on improving medication adherence: meta-analysis of randomized trials.
Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders.
Conflict of Interest: DSW has received a grant from Queen Mary Innovation to design medication adherence software and has an interest in its development.
Authorship: All authors had access to the data and a role in writing the manuscript.
Wald et al1 compared 1-way vs 2-way text messaging for medication adherence, and conclude that 2-way text messaging improves medication adherence, whereas one-way text messaging has little or no effect. Two issues caught our attention. The first is that the trial by Mbuagbaw et al2 is grouped as a 1-way trial even though it is a 2-way trial; participants were offered the opportunity to respond to the text messages by text or by calling. The second issue is that the numbers don't add up. We used the numbers reported in the Wald paper1 and found slightly different results.
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