Abstract
Background
Findings on the association between fish consumption and acute coronary syndrome are
inconsistent. We assessed the role of fish consumption in acute coronary syndrome
by conducting a dose-response meta-analysis.
Methods
We conducted a literature search of MEDLINE and Embase databases from 1966 to June
2013 for prospective cohort and case-control studies that evaluated the association
between fish consumption and acute coronary syndrome among general populations without
cardiovascular disease history. Additional studies were identified via hand search
of references of relevant articles. Estimates of relative risk (RR) were pooled using
random-effects model. Sex and age effects were also evaluated.
Results
Our search retrieved 11 prospective cohort and 8 case-control studies, totaling 408,305
participants. Among prospective cohort studies, the highest category of fish consumption
(ie, ≥4 times per week) was associated with the greatest risk reduction in acute coronary
syndrome (RR 0.79; 95% confidence interval [CI], 0.70-0.89). In dose-response analysis,
each additional 100-g serving of fish per week was associated with a 5% reduced risk
(RR per serving 0.95; 95% CI, 0.92-0.97). Subgroup analysis and meta-regression suggested
that the risk reduction did not differ across sex or age groups. No heterogeneity
was observed among prospective cohort (P = .73) and case-control (P = .29) studies. There was no evidence of publication bias.
Conclusion
Our meta-analysis demonstrated that there is an inverse association between fish consumption
and the risk of acute coronary syndrome. Fish consumption appears beneficial in the
primary prevention of acute coronary syndrome, and higher consumption is associated
with greater protection.
Keywords
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Article Info
Publication History
Published online: May 03, 2014
Footnotes
Funding: SSLLY is supported by a health professional training award from the Fonds de la Recherche en Santé du Québec . LP is funded by a James McGill Chair at McGill University.
Conflict of Interest: None.
Authorship: All authors had access to the data and played a role in writing this manuscript.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
