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Dietary Fortification of Aspirin: A Novel Modality for Cancer Prevention

      Two important meta-analyses recently established the definitive additional benefit of long-term use of aspirin in the prevention of cancer development and risk of death.
      • Mills E.J.
      • Wu P.
      • Alberton M.
      • Kanters S.
      • Lanas A.
      • Lester R.
      Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials.
      • Rothwell P.M.
      • Fowkes F.G.
      • Belch J.F.F.
      • Ogawa H.
      • Warlow C.P.
      • Meade T.W.
      Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.
      The extended use of aspirin has shown reductions in cancer incidence and mortality with its low case-fatality (decreasing metastases), which add to the case for daily aspirin as a potential chemopreventive agent against cancers.
      • Rothwell P.M.
      • Wilson M.
      • Price J.F.
      • Belch J.F.
      • Meade T.W.
      • Mehta Z.
      Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.
      • Algra A.M.
      • Rothwell P.M.
      Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.
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      References

        • Mills E.J.
        • Wu P.
        • Alberton M.
        • Kanters S.
        • Lanas A.
        • Lester R.
        Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials.
        Am J Med. 2012; 125: 560-567
        • Rothwell P.M.
        • Fowkes F.G.
        • Belch J.F.F.
        • Ogawa H.
        • Warlow C.P.
        • Meade T.W.
        Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.
        Lancet. 2011; 377: 31-41
        • Rothwell P.M.
        • Wilson M.
        • Price J.F.
        • Belch J.F.
        • Meade T.W.
        • Mehta Z.
        Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.
        Lancet. 2012; 379 (28): 1591-1601
        • Algra A.M.
        • Rothwell P.M.
        Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials.
        Lancet Oncol. 2012; 13: 518-527

      Linked Article

      • Low-dose Aspirin and Cancer Mortality: A Meta-analysis of Randomized Trials
        The American Journal of MedicineVol. 125Issue 6
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          Low-dose aspirin is a common strategy for preventing cardiovascular disease and associated mortality. A recent individual patient data meta-analysis of 8 trials of low- and high-dose aspirin, with long-term follow-up, found important reductions in cancer mortality. We aimed to determine whether cancer mortality also is reduced by low-dose aspirin in the shorter term.
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