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Funding: INVEST was funded by a grant from Abbott Laboratories and the University of Florida Opportunity Fund.
Conflict of Interest: Drs. Bavry, Khaliq, and Gong have no financial disclosures. Dr. Handberg received grant support from the National Institutes of Health (NIH) (National Heart, Lung and Blood Institute [NHLBI]), Abbott Laboratories, Fujisawa, Pfizer, and GlaxoSmithKline. Dr. Cooper-DeHoff received research funding from Abbott Laboratories during the conduct of INVEST and is currently receiving funding from NIH (NHLBI) K23HL086558. Dr. Pepine received research grants from NIH (NHLBI), Baxter, Pfizer, GlaxoSmithKline, and Bioheart, Inc. and is a consultant for Abbott Laboratories, Forest Laboratories, Novartis/Cleveland Clinic, NicOx, Angioblast, Sanofi-Aventis, NHLBI, NIH, Medtelligence, and SLACK Inc. Drs. Handberg and Pepine have received educational grants from the Vascular Biology Working Group (AstraZeneca, Sanofi-Aventis, Schering-Plough, Daiichi-Sankyo Lilly, AtCor Medical, and XOMA).
Authorship: This work is original, and all authors significantly contributed to this paper and accept responsibility for its scientific content.
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- Aspirin and the Harmful Effect of NSAIDsThe American Journal of MedicineVol. 125Issue 2
- PreviewThe article by Bavry et al1 reporting the recurrence of myocardial infarction after the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with established cardiovascular disease is of great interest and of relevance for clinicians working in the “real world.” Although the mechanism for the harmful effect of NSAIDs remains poorly understood, it is feasible that NSAIDs would induce an imbalance between cyclooxygenase-2 (COX-2)-derived prostacyclin (PGI2) and the COX-1-derived thromboxane (TXA2).