Abstract
Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder
of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality,
particularly in patients with concomitant disease. In addition, overly rapid correction
of chronic hyponatremia can cause severe neurologic deficits and death, and optimal
treatment strategies for such cases are not established. An expert panel assessed
the potential contributions of aquaretic nonpeptide small-molecule arginine vasopressin
receptor (AVPR) antagonists to hyponatremia therapies. This review presents their
conclusions, including identification of appropriate treatment populations and possible
future indications for aquaretic AVPR antagonists.
Keywords
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