Office-Based Management of Allergic Rhinitis in Adults


      Allergic rhinitis (AR), the most common form of rhinitis, affects 10% to 30% of adults. However, the prevalence of AR actually may be underestimated. Rhinitis is caused by allergic, nonallergic, infectious, hormonal, occupational, and other factors. Proper management of AR requires that the correct diagnosis be made; the clinical history and physical examination are key. Controlled studies support the utility of several available treatments that produce fewer symptoms, improve quality of life, and prevent comorbidities.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Dykewicz M.S.
        • Fineman S.
        • Skoner D.P.
        • et al.
        • American Academy of Allergy, Asthma and Immunology
        Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force on Practice Parameters in Allergy, Asthma and Immunology.
        Ann Allergy Asthma Immunol. 1998; 81: 478-518
        • Bousquet J.
        • Van Cauwenberge P.
        • Khaltaev N.
        Allergic rhinitis and its impact on asthma.
        J Allergy Clin Immunol. 2001; 108: S147-S334
        • Skoner D.P.
        Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis.
        J Allergy Clin Immunol. 2001; 108: S2-S8
        • Waikart L.
        • Liberman P.
        Nonallergic rhinitis.
        in: deShazo R. Conn’s Current Therapy. Elsevier, NY2006: 258-263
        • Plautt M.
        • Valentine M.D.
        Allergic rhinitis.
        N Engl J Med. 2005; 353: 1934-1944
        • Rosenwasser L.J.
        Treatment of allergic rhinitis.
        Am J Med. 2002; 113: 17S-24S
        • Weiner J.M.
        • Abramson M.J.
        • Puy R.M.
        Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomized controlled trials.
        BMJ. 1998; 317: 1624-1629
        • Meltzer E.O.
        Evaluation of the optimal oral antihistamine for patients with allergic rhinitis.
        Mayo Clin Proc. 2005; 80: 1170-1176
        • Lieberman P.L.
        • Settipane R.A.
        Azelastine nasal spray: a review of pharmacology and clinical efficacy in allergic and nonallergic rhinitis.
        Allergy Asthma Proc. 2003; 24: 95-105
        • Wilson A.M.
        • O’Byrne P.M.
        • Parameswaran K.
        Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis.
        Am J Med. 2004; 116: 338-344
        • Pleskow W.
        • Grubbe R.
        • Weiss S.
        • Lutsky B.
        Efficacy and safety of an extended-release formulation of desloratadine and pseudoephedrine vs the individual components in the treatment of seasonal allergic rhinitis.
        Ann Allergy Asthma Immunol. 2005; 94: 348-354
      1. Committee of Safety of Medicines. Desensitizing vaccines. BMJ. 1986;293:948.

        • Durham S.R.
        • Walker S.M.
        • Varga E.M.
        • et al.
        Long-term efficacy of grass-pollen immunotherapy.
        N Engl J Med. 1999; 341: 468-475